Apo E polymorphism associates with body fatness independently of plasma lipids in middle age men -the aragon workers health study
Tejedor, M. Teresa (Universidad de Zaragoza) ; Garcia-Sobreviela, Maria Pilar ; Ledesma, Marta ; Arbones-Mainar, Jose M.
Resumen: Background: The apolipoprotein E (APOE) gene is polymorphic, encoding one of 3 common alleles (e2, e3, e4) produced from combinations of 2 non-synonymous SNPs (rs429358 and rs7412). APOE plays an important role controlling plasma lipids but its association with adipocyte functionality and body fatness remains to be determined.
Methods: We analyzed fasting plasma lipids and genotyped the two main APOE-SNPs (rs429358 and rs7412), both located in the fourth exon of the APOE, in 4660 Caucasian middle-aged men free of cardiovascular disease.
Results: The rs7412 SNP, which determines the APOE2 isoform, was significantly associated with Body Mass Index (BMI) and Waist Girth (WG) in a multivariate model accounting for age, smoking status and plasma lipids. BMI and WG were highest in TT homozygotes and lowest in CC homozygotes. This effect was independent of the rs429358 SNP, which failed to show any association with the BMI and WG variables. The odds ratio of being obese (BMI.30) for individuals carrying the APOe2 allele, present in 14% of the cohort and defined by the rs7412 SNP, was also significant in this multivariate model, with an OR of 1.27 (95% CI: 1.01–1.59).
Conclusions: This study provides an evidence of a lipid-independent association between the APOE SNP rs7412 and body fatness surrogates, BMI and WG, in a large cohort of middle-aged males.
Idioma: Inglés
DOI: 10.1371/journal.pone.0108605
Año: 2014
Publicado en: PLoS One 9, 9 (2014), e108605 [5 pp]
ISSN: 1932-6203
Factor impacto JCR: 3.234 (2014)
Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 8 / 56 = 0.143 (2014) - Q1 - T1
Tipo y forma: Article (Published version)
Área (Departamento): Genética (Departamento de Anatomía, Embriología y Genética Animal)
Exportado de SIDERAL (2017-02-22-08:46:15)
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Methods: We analyzed fasting plasma lipids and genotyped the two main APOE-SNPs (rs429358 and rs7412), both located in the fourth exon of the APOE, in 4660 Caucasian middle-aged men free of cardiovascular disease.
Results: The rs7412 SNP, which determines the APOE2 isoform, was significantly associated with Body Mass Index (BMI) and Waist Girth (WG) in a multivariate model accounting for age, smoking status and plasma lipids. BMI and WG were highest in TT homozygotes and lowest in CC homozygotes. This effect was independent of the rs429358 SNP, which failed to show any association with the BMI and WG variables. The odds ratio of being obese (BMI.30) for individuals carrying the APOe2 allele, present in 14% of the cohort and defined by the rs7412 SNP, was also significant in this multivariate model, with an OR of 1.27 (95% CI: 1.01–1.59).
Conclusions: This study provides an evidence of a lipid-independent association between the APOE SNP rs7412 and body fatness surrogates, BMI and WG, in a large cohort of middle-aged males.
Idioma: Inglés
DOI: 10.1371/journal.pone.0108605
Año: 2014
Publicado en: PLoS One 9, 9 (2014), e108605 [5 pp]
ISSN: 1932-6203
Factor impacto JCR: 3.234 (2014)
Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 8 / 56 = 0.143 (2014) - Q1 - T1
Tipo y forma: Article (Published version)
Área (Departamento): Genética (Departamento de Anatomía, Embriología y Genética Animal)
Exportado de SIDERAL (2017-02-22-08:46:15)
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articulos > articulos-por-area > genetica
Notice créée le 2016-12-14, modifiée le 2017-03-27