000057852 001__ 57852
000057852 005__ 20170327111914.0
000057852 0247_ $$2doi$$a10.1371/journal.pone.0108605
000057852 0248_ $$2sideral$$a94565
000057852 037__ $$aART-2014-94565
000057852 041__ $$aeng
000057852 100__ $$0(orcid)0000-0001-5026-5144$$aTejedor, M. Teresa$$uUniversidad de Zaragoza
000057852 245__ $$aApo E polymorphism associates with body fatness independently of plasma lipids in middle age men -the aragon workers health study
000057852 260__ $$c2014
000057852 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057852 5203_ $$aBackground: The apolipoprotein E (APOE) gene is polymorphic, encoding one of 3 common alleles (e2, e3, e4) produced from combinations of 2 non-synonymous SNPs (rs429358 and rs7412). APOE plays an important role controlling plasma lipids but its association with adipocyte functionality and body fatness remains to be determined.
Methods: We analyzed fasting plasma lipids and genotyped the two main APOE-SNPs (rs429358 and rs7412), both located in the fourth exon of the APOE, in 4660 Caucasian middle-aged men free of cardiovascular disease.
Results: The rs7412 SNP, which determines the APOE2 isoform, was significantly associated with Body Mass Index (BMI) and Waist Girth (WG) in a multivariate model accounting for age, smoking status and plasma lipids. BMI and WG were highest in TT homozygotes and lowest in CC homozygotes. This effect was independent of the rs429358 SNP, which failed to show any association with the BMI and WG variables. The odds ratio of being obese (BMI.30) for individuals carrying the APOe2 allele, present in 14% of the cohort and defined by the rs7412 SNP, was also significant in this multivariate model, with an OR of 1.27 (95% CI: 1.01–1.59).
Conclusions: This study provides an evidence of a lipid-independent association between the APOE SNP rs7412 and body fatness surrogates, BMI and WG, in a large cohort of middle-aged males.
000057852 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057852 590__ $$a3.234$$b2014
000057852 591__ $$aMULTIDISCIPLINARY SCIENCES$$b8 / 56 = 0.143$$c2014$$dQ1$$eT1
000057852 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057852 700__ $$aGarcia-Sobreviela, Maria Pilar
000057852 700__ $$aLedesma, Marta
000057852 700__ $$0(orcid)0000-0002-8982-3737$$aArbones-Mainar, Jose M.
000057852 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDepartamento de Anatomía, Embriología y Genética Animal$$cGenética
000057852 773__ $$g9, 9 (2014), e108605 [5 pp]$$pPLoS One$$tPLoS One$$x1932-6203
000057852 8564_ $$s239403$$uhttps://zaguan.unizar.es/record/57852/files/texto_completo.pdf$$yVersión publicada
000057852 8564_ $$s115045$$uhttps://zaguan.unizar.es/record/57852/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057852 909CO $$ooai:zaguan.unizar.es:57852$$particulos$$pdriver
000057852 951__ $$a2017-02-22-08:46:15
000057852 980__ $$aARTICLE