Extensive gene content variation in the Brachypodium distachyon pan-genome correlates with population structure
Gordon, S.P. ; Contreras-Moreira, B. (Universidad de Zaragoza) ; Woods, D.P. ; Des Marais, D.L. ; Burgess, D. ; Shu, S. ; Stritt, C. ; Roulin, A.C. ; Schackwitz, W. ; Tyler, L. ; Martin, J. ; Lipzen, A. ; Dochy, N. ; Phillips, J. ; Barry, K. ; Geuten, K. ; Budak, H. ; Juenger, T.E. ; Amasino, R. ; Caicedo, A.L. ; Goodstein, D. ; Davidson, P. ; Mur, L.A.J. ; Figueroa, M. ; Freeling, M. ; Catalan, P. (Universidad de Zaragoza) ; Vogel, J.P.
Resumen: While prokaryotic pan-genomes have been shown to contain many more genes than any individual organism, the prevalence and functional significance of differentially present genes in eukaryotes remains poorly understood. Whole-genome de novo assembly and annotation of 54 lines of the grass Brachypodium distachyon yield a pan-genome containing nearly twice the number of genes found in any individual genome. Genes present in all lines are enriched for essential biological functions, while genes present in only some lines are enriched for conditionally beneficial functions (e.g., defense and development), display faster evolutionary rates, lie closer to transposable elements and are less likely to be syntenic with orthologous genes in other grasses. Our data suggest that differentially present genes contribute substantially to phenotypic variation within a eukaryote species, these genes have a major influence in population genetics, and transposable elements play a key role in pan-genome evolution.
Idioma: Inglés
DOI: 10.1038/s41467-017-02292-8
Año: 2017
Publicado en: Nature Communications 8, 1 (2017), 2184 [13 pp]
ISSN: 2041-1723
Factor impacto JCR: 12.353 (2017)
Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 3 / 64 = 0.047 (2017) - Q1 - T1
Factor impacto SCIMAGO: 6.582 - Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q1) - Physics and Astronomy (miscellaneous) (Q1) - Chemistry (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA/Bioflora
Financiación: info:eu-repo/grantAgreement/ES/DGA/GA-LC-059-2011
Financiación: info:eu-repo/grantAgreement/ES/MINECO/AGL2013-48756-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CGL2012-39953-C02-01
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CGL2016-79790-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CSIC13-4E-2490
Tipo y forma: Article (Published version)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)
Área (Departamento): Área Botánica (Dpto. CC.Agrar.y Medio Natural)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Exportado de SIDERAL (2019-07-09-12:45:41)
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Idioma: Inglés
DOI: 10.1038/s41467-017-02292-8
Año: 2017
Publicado en: Nature Communications 8, 1 (2017), 2184 [13 pp]
ISSN: 2041-1723
Factor impacto JCR: 12.353 (2017)
Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 3 / 64 = 0.047 (2017) - Q1 - T1
Factor impacto SCIMAGO: 6.582 - Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q1) - Physics and Astronomy (miscellaneous) (Q1) - Chemistry (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/ES/DGA/Bioflora
Financiación: info:eu-repo/grantAgreement/ES/DGA/GA-LC-059-2011
Financiación: info:eu-repo/grantAgreement/ES/MINECO/AGL2013-48756-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CGL2012-39953-C02-01
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CGL2016-79790-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CSIC13-4E-2490
Tipo y forma: Article (Published version)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)
Área (Departamento): Área Botánica (Dpto. CC.Agrar.y Medio Natural)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Exportado de SIDERAL (2019-07-09-12:45:41)
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Record created 2018-02-15, last modified 2019-07-09