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Resumen: Herein we report the synthesis of “clickable” magnetic nanoparticles (MNPs) stable in suspension in physiological media for bioorthogonal click chemistry applications. These MNPs incorporate into their coating a cyclooctynyl derivative for strain-promoted azide–alkyne (SPAAC) cycloaddition and either a polyethylene glycol or a glucose moiety to ensure MNP stability in physiological media. Their reactivity towards azide-functionalised Si surfaces was investigated, demonstrating their potential as bioorthogonal probes.
Idioma: Inglés
DOI: 10.1039/c7nj01822c
Año: 2017
Publicado en: NEW JOURNAL OF CHEMISTRY 19 (2017), [6 pp.]
ISSN: 1144-0546
Factor impacto JCR: 3.201 (2017)
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 65 / 171 = 0.38 (2017) - Q2 - T2
Factor impacto SCIMAGO: 0.864 - Chemistry (miscellaneous) (Q1) - Materials Chemistry (Q1) - Catalysis (Q2)

Financiación: info:eu-repo/grantAgreement/EC/H2020/657215/EU/Cell-surface immobilized vs. internalized magnetic nanoparticles for magnetic hyperthermia studies/OUTstandINg
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-R
Financiación: info:eu-repo/grantAgreement/ES/UZ/JIUZ-2015-CIE-03
Tipo y forma: Article (PrePrint)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)

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