Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis
Ortiz-Lucas, M. ; Tobias, A. ; Saz, P. (Universidad de Zaragoza) ; Sebastián, J.J. (Universidad de Zaragoza)
Resumen: Background and objectives: immune system alteration in irritable bowel syndrome (IBS) patients may be modulated by probiotics. We assessed the efficacy of some probiotic species in alleviating characteristic IBS symptoms. Material and methods: a meta-analysis of all identified randomized controlled trials comparing probiotics with placebo in treating IBS symptoms was performed with continuous data summarized using standardized mean differences (SMDs) with 95% confidence intervals (95% CIs), where appropriate. The randomeffects model was employed in cases of heterogeneity; otherwise, fixed-effects models were used. Results: meta-analysis was performed with 10 of 24 studies identified as suitable for inclusion. Probiotics improved pain scores if they contained Bifidobacterium breve (SMD, -0.34; 95% CI, -0.66; -0.02), Bifidobacterium longum (SMD, -0.48; 95% CI, -0.91; -0.06), or Lactobacillus acidophilus (SMD, -0.31; 95% CI, -0.61; -0.01) species. Distension scores were improved by probiotics containing B. breve (SMD, -0.45; 95% CI, -0.77; -0.13), Bifidobacterium infantis, Lactobacillus casei, or Lactobacillus plantarum(SMD, -0.53; 95% CI, -1.00; -0.06) species. All probiotic species tested improved flatulence: B. breve (SMD, -0.42; 95% CI, -0.75; -0.10), B. infantis, L. casei, L. plantarum(SMD, -0.60; 95% CI, -1.07; -0.13), B. longum, L. acidophilus, Lactobacillus bulgaricus, and Streptococcus salivarius ssp. thermophilus (SMD, -0.61; 95% CI, -1.01; -0.21). There was not a clear positive effect of probiotics concerning the quality of life. Conclusions: some probiotics are an effective therapeutic option for IBS patients, and the effects on each IBS symptom are likely species-specific. Future studies must focus on the role of probiotics in modulating intestinal microbiota and the immune system while considering individual patient symptom profiles.
Idioma: Inglés
DOI: 10.4321/S1130-01082013000100005
Año: 2013
Publicado en: Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 105, 1 (2013), 19-36
ISSN: 1130-0108
Factor impacto JCR: 1.317 (2013)
Categ. JCR: GASTROENTEROLOGY & HEPATOLOGY rank: 64 / 75 = 0.853 (2013) - Q4 - T3
Tipo y forma: Article (Published version)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
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Idioma: Inglés
DOI: 10.4321/S1130-01082013000100005
Año: 2013
Publicado en: Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 105, 1 (2013), 19-36
ISSN: 1130-0108
Factor impacto JCR: 1.317 (2013)
Categ. JCR: GASTROENTEROLOGY & HEPATOLOGY rank: 64 / 75 = 0.853 (2013) - Q4 - T3
Tipo y forma: Article (Published version)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2019-08-19-09:51:58)
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Record created 2017-09-11, last modified 2019-08-19