Polymeric micelles from block copolymers containing 2,6-diacylaminopyridine units for encapsulation of hydrophobic drugs
Oriol Langa, Luis Teodoro (Universidad de Zaragoza) ; Concellón, A. (Universidad de Zaragoza) ; Clavería-Gimeno, R. ; Velázquez-Campoy, A. (Universidad de Zaragoza) ; Abian, O. (Universidad de Zaragoza) ; Piñol, M. (Universidad de Zaragoza)
Resumen: The paper describes the synthesis and characterization of novel amphiphilic block copolymers composed of a hydrophilic (polyethylene glycol) block and a hydrophobic polymetacrylate block with pendant 2,6-acylaminopyridine units. As demonstrated by TEM, these polymers are capable of forming stable spherical micelles in water with diameters of 18-25 nm, depending on the average molar mass, determined by dynamic light scattering. The polymeric micelles are sensitive to pH and can encapsulate hydrophobic molecules such as Nile Red. The cytotoxicity of the block copolymers has been tested in HeLa and Lunet cell lines and proved to be adequate. The polymeric micelles have been used to load camptothecin (CPT), an effective antiviral against hepatitis C virus (HCV), by simple physical diffusion. The antiviral activity against HVC of these CPT-loaded polymeric micelles has been tested on Huh 5-2 Lunet cells, demonstrating the potential of these polymers as nanocarriers for drug delivery applications.
Idioma: Inglés
DOI: 10.1039/c6ra01714b
Año: 2016
Publicado en: RSC Advances 6, 29 (2016), 24066 - 24075
ISSN: 2046-2069
Factor impacto JCR: 3.108 (2016)
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 59 / 166 = 0.355 (2016) - Q2 - T2
Factor impacto SCIMAGO: 0.889 - Chemistry (miscellaneous) (Q1) - Chemical Engineering (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BFU2013-47064-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/MAT2014-55205-P
Tipo y forma: Article (Published version)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2021-09-02-08:33:31)
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Idioma: Inglés
DOI: 10.1039/c6ra01714b
Año: 2016
Publicado en: RSC Advances 6, 29 (2016), 24066 - 24075
ISSN: 2046-2069
Factor impacto JCR: 3.108 (2016)
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 59 / 166 = 0.355 (2016) - Q2 - T2
Factor impacto SCIMAGO: 0.889 - Chemistry (miscellaneous) (Q1) - Chemical Engineering (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/ES/MINECO/BFU2013-47064-P
Financiación: info:eu-repo/grantAgreement/ES/MINECO/MAT2014-55205-P
Tipo y forma: Article (Published version)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2021-09-02-08:33:31)
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Record created 2017-06-20, last modified 2021-09-02