Polyethylene glycols: An effective strategy for limiting liver ischemia reperfusion injury
Pasut, G. ; Panisello, A. ; Folch-Puy, E. ; Lopez, A. ; Castro-Benítez, C. ; Calvo, M. ; Carbonell, T. ; García-Gil, A. (Universidad de Zaragoza) ; Adam, R. ; Roselló-Catafau, J.
Resumen: Liver ischemia-reperfusion injury (IRI) is an inherent feature of liver surgery and liver transplantation in which damage to a hypoxic organ (ischemia) is exacerbated following the return of oxygen delivery (reperfusion). IRI is a major cause of primary non-function after transplantation and may lead to graft rejection, regardless of immunological considerations. The immediate response involves the disruption of cellular mitochondrial oxidative phosphorylation and the accumulation of metabolic intermediates during the ischemic period, and oxidative stress during blood flow restoration. Moreover, a complex cascade of inflammatory mediators is generated during reperfusion, contributing to the extension of the damage and finally to organ failure. A variety of pharmacological interventions (antioxidants, anti-cytokines, etc.) have been proposed to alleviate graft injury but their usefulness is limited by the local and specific action of the drugs and by their potential undesirable toxic effects. Polyethylene glycols (PEGs), which are non-toxic water-soluble compounds approved by the FDA, have been widely used as a vehicle or a base in food, cosmetics and pharmaceuticals, and also as adjuvants for ameliorating drug pharmacokinetics. Some PEGs are also currently used as additives in organ preservation solutions prior to transplantation in order to limit the damage associated with cold ischemia reperfusion. More recently, the administration of PEGs of different molecular weights by intravenous injection has emerged as a new therapeutic tool to protect liver grafts from IRI. In this review, we summarize the current knowledge concerning the use of PEGs as a useful target for limiting liver IRI.
Idioma: Inglés
DOI: 10.3748/wjg.v22.i28.6501
Año: 2016
Publicado en: WORLD JOURNAL OF GASTROENTEROLOGY 22, 28 (2016), 6501-6508
ISSN: 1007-9327
Factor impacto JCR: 3.365 (2016)
Categ. JCR: GASTROENTEROLOGY & HEPATOLOGY rank: 29 / 79 = 0.367 (2016) - Q2 - T2
Factor impacto SCIMAGO: 1.272 - Medicine (miscellaneous) (Q1) - Gastroenterology (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Área Cirugía (Dpto. Cirugía,Ginecol.Obstetr.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
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Idioma: Inglés
DOI: 10.3748/wjg.v22.i28.6501
Año: 2016
Publicado en: WORLD JOURNAL OF GASTROENTEROLOGY 22, 28 (2016), 6501-6508
ISSN: 1007-9327
Factor impacto JCR: 3.365 (2016)
Categ. JCR: GASTROENTEROLOGY & HEPATOLOGY rank: 29 / 79 = 0.367 (2016) - Q2 - T2
Factor impacto SCIMAGO: 1.272 - Medicine (miscellaneous) (Q1) - Gastroenterology (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Área Cirugía (Dpto. Cirugía,Ginecol.Obstetr.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2020-02-21-13:47:13)
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Record created 2017-06-12, last modified 2020-02-21