Universidad de Zaragoza Repository

Resumen: With the increasing concern for sustainability, the use of environmentally friendly media to perform chemical processes has attracted the attention of many research groups. Among them, the use of water, as the unique solvent for reactions, is currently an active area of research. One process of particular interest is the direct nucleophilic substitution of an alcohol avoiding its preliminary transformation into a good leaving group, since one of the by-products in this approach would be water. The direct substitution of allylic, benzylic, and tertiary alcohols has been achieved through SN1-Type reactions with catalytic amounts of Brønsted or Lewis acids; however, organic solvents are often required. In this review, the pioneering SN1 approaches performed in pure water and in the absence of a metal based Lewis acid are compiled and discussed.
Idioma: Inglés
DOI: 10.3390/molecules22040574
Año: 2017
Publicado en: Molecules 22, 4 (2017), 574 [12 pp.]
ISSN: 1420-3049
Factor impacto JCR: 3.098 (2017)
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 68 / 171 = 0.398 (2017) - Q2 - T2
Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 133 / 292 = 0.455 (2017) - Q2 - T2
Factor impacto SCIMAGO: 0.855 - Analytical Chemistry (Q1) - Pharmaceutical Science (Q1) - Chemistry (miscellaneous) (Q1) - Organic Chemistry (Q2) - Physical and Theoretical Chemistry (Q2) - Drug Discovery (Q2) - Medicine (miscellaneous) (Q2) - Molecular Medicine (Q3)

Financiación: info:eu-repo/grantAgreement/ES/DGA/E104
Tipo y forma: Review (Published version)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)

You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

Exportado de SIDERAL (2019-07-09-12:02:57)


Visitas y descargas

Este artículo se encuentra en las siguientes colecciones:
Articles