Monitoring the antimicrobial susceptibility of Gramnegative organisms involved in intraabdominal and urinary tract infections recovered during the SMART study (Spain, 2016 and 2017)
Cantón, R. ; Loza, E. ; Aznar, J. ; Castillo, F.J. (Universidad de Zaragoza) ; Cercenado, E. ; Fraile-Ribot, P.A. ; González-Romo, F. ; López-Hontangas, J.L. ; Rodríguez-Lozano, J. ; Suárez-Barrenechea, A.I. ; Tubau, F. ; Díaz-Regañón, J. ; López-Mendoza, D. ; Seral, C. (Universidad de Zaragoza) ; Calvo, J. ; Domínguez, M.A. ; Pérez Sáenz, J.L. ; Oliver, A. ; García-Castillo, M. ; Prieto, J. ; Aznar, J. ; Rodríguez-Rey, A. ; Pascual, A.
Resumen: OBJECTIVE: Continuous antimicrobial resistance surveillance is recommended by Public Health authorities. We up-dated data from the SMART (Study for Monitoring Antimicrobial Resistance Trends) surveillance study in Spain.
METHODS: The antimicrobial susceptibility data and extended-spectrum beta-lactamase (ESBL) production in isolates recovered from intra-abdominal (IAI) (n=1,429) and urinary tract (UTI) (n=937) infections during the 2016- 2017 SMART study in 10 Spanish hospitals were analysed.
RESULTS: Escherichia coli was the most frequently microorganism isolated (48.3% and 53.7%) followed by Klebsiella spp. (11.5% and 21.9%) in IAIs and UTIs, respectively. Figures for Pseudomonas aeruginosa were 9.0% and 6.1%, being more frequently recovered from patients with nosocomial infections. Overall, 9.9% (IAI) and 14.0% (UTI) of E. coli, Klebsiella spp. and Proteus mirabilis isolates were ESBL-producers, being Klebsiella pneumoniae (34.5%) from UTI of nosocomial origin the most frequent. ESBL-producers were higher in patients >60 years in both IAIs and UTIs. As in previous years, amikacin (96.3%-100% susceptibility), ertapenem (84.2%-100%) and imipenem (70.3%- 100%) were the most active antimicrobials tested among Enterobacterales species. The activity of amoxicillin-clavulanic, piperacillin-tazobactam, and ciprofloxacin susceptibility was lower, particularly among ESBL-producers. Ertapenem susceptibility (88.9%-100%) was retained in ESBL-E. coli isolates that were resistant to these antimicrobials but decreased (28.6%-100%) in similar isolates of K. pneumoniae.
CONCLUSIONS: Continuous antimicrobial resistance surveillance from the SMART study reveals overall maintenance of ESBL-producers in Spain, although with higher presence in isolates from UTIs than from IAIs. Moreover, ertapenem activity was high in E. coli irrespective of ESBL production but decreased in K. pneumoniae, particularly among ESBL-producers.
Idioma: Inglés
Año: 2019
Publicado en: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 32, 2 (2019), 145-155
ISSN: 1988-9518
Originalmente disponible en: Texto completo de la revista
Factor impacto JCR: 1.132 (2019)
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 246 / 270 = 0.911 (2019) - Q4 - T3
Categ. JCR: MICROBIOLOGY rank: 121 / 134 = 0.903 (2019) - Q4 - T3
Factor impacto SCIMAGO: 0.287 - Medicine (miscellaneous) (Q3) - Pharmacology (Q3) - Microbiology (medical) (Q3)
Tipo y forma: Article (Published version)
Área (Departamento): Área Microbiología (Dpto. Microb.Med.Pr.,Sal.Públ.)
Exportado de SIDERAL (2020-07-16-09:32:26)
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METHODS: The antimicrobial susceptibility data and extended-spectrum beta-lactamase (ESBL) production in isolates recovered from intra-abdominal (IAI) (n=1,429) and urinary tract (UTI) (n=937) infections during the 2016- 2017 SMART study in 10 Spanish hospitals were analysed.
RESULTS: Escherichia coli was the most frequently microorganism isolated (48.3% and 53.7%) followed by Klebsiella spp. (11.5% and 21.9%) in IAIs and UTIs, respectively. Figures for Pseudomonas aeruginosa were 9.0% and 6.1%, being more frequently recovered from patients with nosocomial infections. Overall, 9.9% (IAI) and 14.0% (UTI) of E. coli, Klebsiella spp. and Proteus mirabilis isolates were ESBL-producers, being Klebsiella pneumoniae (34.5%) from UTI of nosocomial origin the most frequent. ESBL-producers were higher in patients >60 years in both IAIs and UTIs. As in previous years, amikacin (96.3%-100% susceptibility), ertapenem (84.2%-100%) and imipenem (70.3%- 100%) were the most active antimicrobials tested among Enterobacterales species. The activity of amoxicillin-clavulanic, piperacillin-tazobactam, and ciprofloxacin susceptibility was lower, particularly among ESBL-producers. Ertapenem susceptibility (88.9%-100%) was retained in ESBL-E. coli isolates that were resistant to these antimicrobials but decreased (28.6%-100%) in similar isolates of K. pneumoniae.
CONCLUSIONS: Continuous antimicrobial resistance surveillance from the SMART study reveals overall maintenance of ESBL-producers in Spain, although with higher presence in isolates from UTIs than from IAIs. Moreover, ertapenem activity was high in E. coli irrespective of ESBL production but decreased in K. pneumoniae, particularly among ESBL-producers.
Idioma: Inglés
Año: 2019
Publicado en: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 32, 2 (2019), 145-155
ISSN: 1988-9518
Originalmente disponible en: Texto completo de la revista
Factor impacto JCR: 1.132 (2019)
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 246 / 270 = 0.911 (2019) - Q4 - T3
Categ. JCR: MICROBIOLOGY rank: 121 / 134 = 0.903 (2019) - Q4 - T3
Factor impacto SCIMAGO: 0.287 - Medicine (miscellaneous) (Q3) - Pharmacology (Q3) - Microbiology (medical) (Q3)
Tipo y forma: Article (Published version)
Área (Departamento): Área Microbiología (Dpto. Microb.Med.Pr.,Sal.Públ.)
Exportado de SIDERAL (2020-07-16-09:32:26)
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Notice créée le 2019-05-23, modifiée le 2020-07-16