000079129 001__ 79129
000079129 005__ 20200117221653.0
000079129 0247_ $$2doi$$a10.1111/eci.12706
000079129 0248_ $$2sideral$$a97378
000079129 037__ $$aART-2017-97378
000079129 041__ $$aeng
000079129 100__ $$aArellano-Orden, Elena
000079129 245__ $$aStent-induced tracheal stenosis can be predicted by IL-8 expression in rabbits
000079129 260__ $$c2017
000079129 5060_ $$aAccess copy available to the general public$$fUnrestricted
000079129 5203_ $$aBackground: bare metal stents may cause complications like fibrous encapsulation, granulation and tracheal stenosis. We investigated the behaviour of three commercially available stents in vivo (rabbits) and in vitro (coculture of those stents with epithelial and fibroblast cell lines). Also, we investigated whether development of tracheal stenosis could be predicted by any biological marker. Materials and methods: the tracheae of 30 rabbits were implanted with either nitinol stents, with or without paclitaxel elution, or a cobalt-based stent. An additional ten rabbits underwent mock implantation (controls). Serial peripheral venous blood samples were taken throughout the study, and several cytokines measured. Animals were euthanized on day 90, with immediate tracheal endoscopy and lavage performed, then necropsy. Results: rabbits with cobalt-based stent exhibited more inflammation and the highest stenosis incidence, with reduced survival. Both in vivo and in vitro, this stent induced higher IL-8 levels than nitinol stents. Most important, the presence of stent-induced tracheal stenosis was closely associated to increase in IL-8 expression in blood just 1 day after tracheal stent implantation: a 1·19-fold increase vs. baseline had 83% sensitivity, 83% specificity, 77% positive predictive value, 88%negative predictive value and 83% accuracy to predict development of stenosis. Conclusions: the cobalt-based stent had the highest incidence of tracheal inflammation and stenosis. On the other hand, the paclitaxel-eluting nitinol stent did not prevent those complications and provoked a marked reaction compared with the bare nitinol stent. Early increase in IL-8 expression in blood after stent implantation could predict development of tracheal stenosis in rabbits.
000079129 536__ $$9info:eu-repo/grantAgreement/ES/FIS/FIS08-0096$$9info:eu-repo/grantAgreement/ES/FIS/FIS08-1424
000079129 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000079129 590__ $$a3.086$$b2017
000079129 591__ $$aMEDICINE, GENERAL & INTERNAL$$b32 / 154 = 0.208$$c2017$$dQ1$$eT1
000079129 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b57 / 133 = 0.429$$c2017$$dQ2$$eT2
000079129 592__ $$a1.321$$b2017
000079129 593__ $$aClinical Biochemistry$$c2017$$dQ1
000079129 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1
000079129 593__ $$aBiochemistry$$c2017$$dQ2
000079129 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000079129 700__ $$0(orcid)0000-0002-8880-6580$$aSerrano, Carolina$$uUniversidad de Zaragoza
000079129 700__ $$aMontes-Worboys, Ana
000079129 700__ $$aSanchez-Lopez, Veronica
000079129 700__ $$0(orcid)0000-0003-0296-1617$$aLaborda, Alicia$$uUniversidad de Zaragoza
000079129 700__ $$0(orcid)0000-0002-3158-7022$$aLostalé, Fernando$$uUniversidad de Zaragoza
000079129 700__ $$0(orcid)0000-0003-3865-0925$$aLahuerta, Celia
000079129 700__ $$aRodriguez-Panadero, Francisco
000079129 700__ $$0(orcid)0000-0002-5618-7519$$aGregorio, Miguel Ángel de$$uUniversidad de Zaragoza
000079129 7102_ $$11010$$2770$$aUniversidad de Zaragoza$$bDpto. Pediatría Radiol.Med.Fís$$cÁrea Radiol. y Medicina Física
000079129 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000079129 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000079129 773__ $$g47, 1 (2017), 84-92$$pEur. j. clin. investig.$$tEUROPEAN JOURNAL OF CLINICAL INVESTIGATION$$x0014-2972
000079129 8564_ $$s472370$$uhttps://zaguan.unizar.es/record/79129/files/texto_completo.pdf$$yPostprint
000079129 8564_ $$s55245$$uhttps://zaguan.unizar.es/record/79129/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000079129 909CO $$ooai:zaguan.unizar.es:79129$$particulos$$pdriver
000079129 951__ $$a2020-01-17-22:09:51
000079129 980__ $$aARTICLE