Atlantis Institut des Sciences Fictives

Resumen: Caspase-3 is the main executor of the apoptotic process. Higher serum caspase-3 concentrations in non-survivor compared to survivor septic patients have been found. The objectives of this work (with the increase of sample size to 308 patients, and the determination of serum caspase-3 concentrations also on days 4 and 8 of diagnosis of severe sepsis) were to know whether an association between serum caspase-3 concentrationss during the first week, degree of apoptosis, sepsis severity, and sepsis mortality exists. We collected serum samples of 308 patients with severe sepsis from eight intensive care units on days 1, 4 and 8 to measure concentrations of caspase-3 and caspase-cleaved cytokeratin (CCCK)-18 (to assess degree of apoptosis). End point was 30-day mortality. We found higher serum concentrations of caspase-3 and CCCK-18 in non-survivors compared to survivors on days 1 (p < 0.001), 4 (p < 0.001), and 8 (p < 0.001). We found an association between serum caspase-3 concentrations on days 1, 4 and 8 of severe sepsis diagnosis and serum CCCK-18 concentrations (p < 0.001), SOFA (p < 0.001), serum acid lactic concentrations (p < 0.001), and 30-day sepsis mortality (p < 0.001). The new findings of this work were that an association between serum caspase-3 concentrations during the first week, apoptosis degree, sepsis severity, and sepsis mortality exists.
Idioma: Inglés
DOI: 10.1007/s10096-017-3129-y
Año: 2018
Publicado en: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 37, 2 (2018), 281-288
ISSN: 0934-9723
Factor impacto JCR: 2.591 (2018)
Categ. JCR: MICROBIOLOGY rank: 78 / 133 = 0.586 (2018) - Q3 - T2
Categ. JCR: INFECTIOUS DISEASES rank: 46 / 89 = 0.517 (2018) - Q3 - T2
Factor impacto SCIMAGO: 1.208 - Infectious Diseases (Q1) - Microbiology (medical) (Q1) - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/INT16-00165
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI14-00220
Tipo y forma: Article (PostPrint)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Exportado de SIDERAL (2020-01-13-14:54:52)


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