000078861 001__ 78861
000078861 005__ 20200707115305.0
000078861 0247_ $$2doi$$a10.3390/inorganics7020013
000078861 0248_ $$2sideral$$a111235
000078861 037__ $$aART-2019-111235
000078861 041__ $$aeng
000078861 100__ $$aGoitia, H.
000078861 245__ $$aCytotoxic gold(I) complexes with amidophosphine ligands containing thiophene moieties
000078861 260__ $$c2019
000078861 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078861 5203_ $$aA new phosphine ligand bearing a thiophene moiety, C 4 H 3 SNHCOCH 2 CH 2 PPh 2 (L), has been prepared by reaction of the aminophosphine Ph 2 PCH 2 CH 2 NH 2 with thiophenecarbonylchloride in the presence of triethylamine. The coordination behavior towards gold(I), gold(III) and silver(I) species has been studied and several metal compounds of different stoichiometry have been achieved, such as [AuL 2 ]OTf, [AuXL] (X = Cl, C 6 F 5 ), [Au(C 6 F 5 ) 3 L], [AgL 2 ]OTf or [Ag(OTf)L]. Additionally, the reactivity of the chloride gold(I) species with biologically relevant thiolates was explored, thus obtaining the neutral thiolate compounds [AuL(SR)] (SR = 2-thiocitosine, 2-thiolpyridine, 2-thiouracil, 2-thionicotinic acid, 2, 3, 4, 6-tetra-6-acetyl-1-thiol-ß-D-glucopyranosato or thiopurine). The antitumor activity of the compounds was measured by the MTT method in several cancer cells and the complexes exhibit excellent cytotoxic activity.
000078861 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/E07-17R$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P
000078861 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000078861 592__ $$a0.482$$b2019
000078861 593__ $$aInorganic Chemistry$$c2019$$dQ2
000078861 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000078861 700__ $$0(orcid)0000-0002-3978-1145$$aVillacampa, M.D.$$uUniversidad de Zaragoza
000078861 700__ $$0(orcid)0000-0003-1984-7538$$aLaguna, A.$$uUniversidad de Zaragoza
000078861 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno, M.C.$$uUniversidad de Zaragoza
000078861 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000078861 773__ $$g7, 2 (2019), 13 [13 pp]$$tInorganics$$x2304-6740
000078861 8564_ $$s612585$$uhttps://zaguan.unizar.es/record/78861/files/texto_completo.pdf$$yVersión publicada
000078861 8564_ $$s111559$$uhttps://zaguan.unizar.es/record/78861/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000078861 909CO $$ooai:zaguan.unizar.es:78861$$particulos$$pdriver
000078861 951__ $$a2020-07-07-11:49:55
000078861 980__ $$aARTICLE