000074907 001__ 74907
000074907 005__ 20190709135447.0
000074907 0247_ $$2doi$$a10.1016/j.eurpolymj.2017.09.020
000074907 0248_ $$2sideral$$a101528
000074907 037__ $$aART-2017-101528
000074907 041__ $$aeng
000074907 100__ $$aKyziol, Agnieszka
000074907 245__ $$aPreparation and characterization of electrospun alginate nanofibers loaded with ciprofloxacin hydrochloride
000074907 260__ $$c2017
000074907 5060_ $$aAccess copy available to the general public$$fUnrestricted
000074907 5203_ $$aAlginate nanofibers were prepared in the presence of poly(ethylene oxide) (PEO), a surfactant Pluronic F-127, and a model drug (ciprofloxacin hydrochloride, CpHCl), all mixed prior to electrospinning. It was demonstrated that addition of a carrier polymer (PEO) and a small amount of surfactant are necessary to obtain uniform alginate fibers with cylindrical shape and regular morphology. Importantly, PEO was completely removed from the resulting nanofibers during cross-linking and stabilization post-treatment. The stable alginate fibers loaded with CpHCl were examined by scanning electron microscopy and the average diameter of the fibers ranged from 109 nm (unloaded fibers) to 161 nm (loaded fibers). The release of a studied antibiotic from the nanofibers, characterized by a final loading efficiency of 51%, was tested in physiological conditions. It was revealed that ca. 24% of CpHCl is released during first 20 h with combined transport mechanism, however with the predominant contribution of Fickian diffusion.
000074907 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000074907 590__ $$a3.741$$b2017
000074907 591__ $$aPOLYMER SCIENCE$$b12 / 87 = 0.138$$c2017$$dQ1$$eT1
000074907 592__ $$a0.996$$b2017
000074907 593__ $$aOrganic Chemistry$$c2017$$dQ1
000074907 593__ $$aPolymers and Plastics$$c2017$$dQ1
000074907 593__ $$aPhysics and Astronomy (miscellaneous)$$c2017$$dQ1
000074907 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000074907 700__ $$aMichna, Justyn
000074907 700__ $$0(orcid)0000-0002-6336-7542$$aMoreno Vidorreta, Iván
000074907 700__ $$0(orcid)0000-0002-0272-3152$$aGamez, Enrique$$uUniversidad de Zaragoza
000074907 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta, Silvia$$uUniversidad de Zaragoza
000074907 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000074907 773__ $$g96 (2017), 350-360$$pEur. Polym. J.$$tEUROPEAN POLYMER JOURNAL$$x0014-3057
000074907 8564_ $$s1035182$$uhttps://zaguan.unizar.es/record/74907/files/texto_completo.pdf$$yPostprint
000074907 8564_ $$s69954$$uhttps://zaguan.unizar.es/record/74907/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000074907 909CO $$ooai:zaguan.unizar.es:74907$$particulos$$pdriver
000074907 951__ $$a2019-07-09-11:39:13
000074907 980__ $$aARTICLE