000071000 001__ 71000
000071000 005__ 20180622124306.0
000071000 0247_ $$2doi$$a10.1186/1471-2466-14-114
000071000 0248_ $$2sideral$$a88531
000071000 037__ $$aART-2014-88531
000071000 041__ $$aeng
000071000 100__ $$aMarin, JM
000071000 245__ $$aEpigenetics modifications and Subclinical Atherosclerosis in Obstructive Sleep Apnea: The EPIOSA study.
000071000 260__ $$c2014
000071000 5060_ $$aAccess copy available to the general public$$fUnrestricted
000071000 5203_ $$aBackground
Obstructive sleep apnea (OSA) is associated with increased risk for cardiovascular morbidity and mortality. Epidemiological and animal models studies generate hypotheses for innovative strategies in OSA management by interferig intermediates mechanisms associated with cardiovascular complications. We have thus initiated the Epigenetics modification in Obstructive Sleep Apnea (EPIOSA) study (ClinicalTrials.gov identifier: NCT02131610).
Methods/design
EPIOSA is a prospective cohort study aiming to recruit 350 participants of caucasian ethnicity and free of other chronic or inflammatory diseases: 300 patients with prevalent OSA and 50 non-OSA subjects. All of them will be follow-up for at least 5 years. Recruitment and study visits are performed in single University-based sleep clinic using standard operating procedures. At baseline and at each one year follow-up examination, patients are subjected to a core phenotyping protocol. This includes a standardized questionnaire and physical examination to determine incident comorbidities and health resources utilization, with a primary focus on cardiovascular events. Confirmatory outcomes information is requested from patient records and the regional Department of Health Services. Every year, OSA status will be assessed by full sleep study and blood samples will be obtained for immediate standard biochemistry, hematology, inflammatory cytokines and cytometry analysis. For biobanking, aliquots of serum, plasma, urine, mRNA and DNA are also obtained. Bilateral carotid echography will be performed to assess subclinical atherosclerosis and atherosclerosis progression. OSA patients are treated according with national guidelines.
Discussion
EPIOSA will enable the prospective evaluation of inflammatory and epigenetics mechanism involved in cardiovascular complication of treated and non-treated patients with OSA compared with non OSA subjects.
000071000 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI12-01275
000071000 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000071000 590__ $$a2.404$$b2014
000071000 591__ $$aRESPIRATORY SYSTEM$$b31 / 57 = 0.544$$c2014$$dQ3$$eT2
000071000 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000071000 700__ $$aArtal, J
000071000 700__ $$aMartin, T
000071000 700__ $$aCarrizo, SJ
000071000 700__ $$aAndres, M
000071000 700__ $$0(orcid)0000-0001-6016-4726$$aMartín Burriel, I$$uUniversidad de Zaragoza
000071000 700__ $$0(orcid)0000-0002-2746-3932$$aBolea, R$$uUniversidad de Zaragoza
000071000 700__ $$0(orcid)0000-0001-6489-8399$$aSanz, A$$uUniversidad de Zaragoza
000071000 700__ $$0(orcid)0000-0001-6256-5478$$aVarona, L$$uUniversidad de Zaragoza
000071000 700__ $$aGodino, J
000071000 700__ $$aGallego, B
000071000 700__ $$aGarcia-Erce, JA
000071000 700__ $$aVillar, I
000071000 700__ $$aGil, V
000071000 700__ $$aForner, M
000071000 700__ $$aCubero, JP
000071000 700__ $$aRos, L.
000071000 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDepartamento de Patología Animal$$cSanidad Animal
000071000 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDepartamento de Anatomía, Embriología y Genética Animal$$cGenética
000071000 773__ $$g14, 114 (2014), 8$$pBMC polm. med.$$tBMC pulmonary medicine$$x1471-2466
000071000 8564_ $$s313003$$uhttp://zaguan.unizar.es/record/71000/files/texto_completo.pdf$$yVersión publicada
000071000 8564_ $$s104741$$uhttp://zaguan.unizar.es/record/71000/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000071000 909CO $$ooai:zaguan.unizar.es:71000$$particulos$$pdriver
000071000 951__ $$a2018-06-22-11:08:07
000071000 980__ $$aARTICLE