000070931 001__ 70931
000070931 005__ 20191127155457.0
000070931 0247_ $$2doi$$a10.1371/journal.pone.0196576
000070931 0248_ $$2sideral$$a106495
000070931 037__ $$aART-2018-106495
000070931 041__ $$aeng
000070931 100__ $$aGarcia-Casal, M.N.
000070931 245__ $$aPerformance and comparability of laboratory methods for measuring ferritin concentrations in human serum or plasma: A systematic review and meta-analysis
000070931 260__ $$c2018
000070931 5060_ $$aAccess copy available to the general public$$fUnrestricted
000070931 5203_ $$aBackground Different laboratory methods are used to quantify ferritin concentrations as a marker of iron status. A systematic review was undertaken to assess the accuracy and comparability of the most used methods for ferritin detection. Methods and findings National and regional databases were searched for prospective, retrospective, sectional, longitudinal and case-control studies containing the characteristics and performance of at least one method for serum/plasma ferritin determinations in humans published to date. The analysis included the comparison between at least 2 methods detailing: sensitivity, precision, accuracy, predictive values, inter-methods adjustment, and use of international reference materials. Pooled method performance was analyzed for each method and across methods. Outcomes Search strategy identified 11893 records. After de-duplication and screening 252 studies were assessed, including 187 studies in the qualitative analysis and 148 in the meta-analysis. The most used methods included radiometric, nonradiometric and agglutination assays. The overall within-run imprecision for the most reported ferritin methods was 6.2±3.4% (CI 5.69–6.70%; n = 171), between-run imprecision 8.9±8.7% (CI 7.44–10.35%; n = 136), and recovery rate 95.6% (CI 91.5–99.7%; n = 94). The pooled regression coefficient was 0.985 among all methods analyzed, and 0.984 when comparing nonradiometric and radiometric methods, without statistical differences in ferritin concentration ranging from 2.3 to 1454 µµg/L. Conclusion The laboratory methods most used to determine ferritin concentrations have comparable accuracy and performance. Registered in PROSPERO CRD42016036222.
000070931 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000070931 590__ $$a2.776$$b2018
000070931 591__ $$aMULTIDISCIPLINARY SCIENCES$$b23 / 69 = 0.333$$c2018$$dQ2$$eT2
000070931 592__ $$a1.1$$b2018
000070931 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2018$$dQ1
000070931 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000070931 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2018$$dQ1
000070931 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000070931 700__ $$aPeña-Rosas, J.P.
000070931 700__ $$aUrrechaga, E.
000070931 700__ $$0(orcid)0000-0002-6012-7412$$aEscanero, J.F.$$uUniversidad de Zaragoza
000070931 700__ $$aHuo, J.
000070931 700__ $$aMartinez, R.X.
000070931 700__ $$aLopez-Perez, L.
000070931 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000070931 773__ $$g13, 5 (2018), e0196576[24 pp]$$pPLoS One$$tPloS one$$x1932-6203
000070931 8564_ $$s549646$$uhttps://zaguan.unizar.es/record/70931/files/texto_completo.pdf$$yVersión publicada
000070931 8564_ $$s96260$$uhttps://zaguan.unizar.es/record/70931/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000070931 909CO $$ooai:zaguan.unizar.es:70931$$particulos$$pdriver
000070931 951__ $$a2019-11-27-15:48:36
000070931 980__ $$aARTICLE