000070687 001__ 70687
000070687 005__ 20190709135422.0
000070687 0247_ $$2doi$$a10.1016/j.jinorgbio.2016.11.009
000070687 0248_ $$2sideral$$a97109
000070687 037__ $$aART-2017-97109
000070687 041__ $$aeng
000070687 100__ $$aSánchez-de-Diego, C.
000070687 245__ $$aThe anticancer effect related to disturbances in redox balance on Caco-2 cells caused by an alkynyl gold(I) complex
000070687 260__ $$c2017
000070687 5060_ $$aAccess copy available to the general public$$fUnrestricted
000070687 5203_ $$aThe alkynyl gold(I) derivative Au(C=CPh)(PTA)] (PTA = 1, 3, 5-triaza-7-phosphaadamantane) induces apoptosis in colorectal carcinoma tumour cells (Caco-2) without affecting to normal enterocytes. Au(C=CPh)(PTA)] is a slight lipophilic drug, stable in PBS (Phosphate Buffered Saline) and able to bind BSA (Bovin Serum Albumin) by hydrophobic interactions. Once inside the cell, Au(C=CPh)(PTA)] targets seleno proteins such as Thioredoxin Reductase 1, increasing ROS (Reactive Oxygen Species) levels, reducing cell viability and proliferation and inducing mitochondrial apoptotic pathway, pro-apoptotic and anti-apoptotic protein imbalance, loss of mitochondrial membrane potential, cytochrome c release and activation of caspases 9 and 3. Moreover, unlike other metal-based drugs such as cisplatin, Au(C=CPh)(PTA)] does not target nucleic acid, reducing the risk of side mutation in the DNA. In consequence, our results predict a promising future for Au(C=CPh)(PTA)] as a chemotherapeutic agent for colorectal carcinoma.
000070687 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A32$$9info:eu-repo/grantAgreement/ES/DGA/E104$$9info:eu-repo/grantAgreement/ES/ISCIII/CB06-03-1012$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2013-48635-C2-1-P$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2013-41651-R
000070687 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000070687 590__ $$a3.063$$b2017
000070687 591__ $$aCHEMISTRY, INORGANIC & NUCLEAR$$b10 / 45 = 0.222$$c2017$$dQ1$$eT1
000070687 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b137 / 292 = 0.469$$c2017$$dQ2$$eT2
000070687 592__ $$a0.743$$b2017
000070687 593__ $$aInorganic Chemistry$$c2017$$dQ2
000070687 593__ $$aBiochemistry$$c2017$$dQ3
000070687 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000070687 700__ $$aMármol, I.
000070687 700__ $$aPérez, R.
000070687 700__ $$aGascón, S.$$uUniversidad de Zaragoza
000070687 700__ $$0(orcid)0000-0002-3595-7668$$aRodriguez-Yoldi, M.$$uUniversidad de Zaragoza
000070687 700__ $$0(orcid)0000-0003-2457-3674$$aCerrada, E.$$uUniversidad de Zaragoza
000070687 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000070687 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000070687 7102_ $$11009$$2X$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Técnica. Lab. y Talleres
000070687 773__ $$g166 (2017), 108-121$$pJ. inorg. biochem.$$tJOURNAL OF INORGANIC BIOCHEMISTRY$$x0162-0134
000070687 8564_ $$s788742$$uhttps://zaguan.unizar.es/record/70687/files/texto_completo.pdf$$yPostprint
000070687 8564_ $$s45669$$uhttps://zaguan.unizar.es/record/70687/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000070687 909CO $$ooai:zaguan.unizar.es:70687$$particulos$$pdriver
000070687 951__ $$a2019-07-09-11:27:20
000070687 980__ $$aARTICLE