000070676 001__ 70676 000070676 005__ 20200221144304.0 000070676 0247_ $$2doi$$a10.1155/2016/5856075 000070676 0248_ $$2sideral$$a106045 000070676 037__ $$aART-2016-106045 000070676 041__ $$aeng 000070676 100__ $$aFigus, M. 000070676 245__ $$aInnovations in Glaucoma Surgery: Improving the Results 000070676 260__ $$c2016 000070676 5060_ $$aAccess copy available to the general public$$fUnrestricted 000070676 5203_ $$aGlaucoma still represents the most frequent cause of irreversible blindness worldwide. The technological advances lead to innovative surgeries, which are rapidly introduced in clinical practice. New devices to lower intraocular pressure without opening the eye wall, bypassing the trabecular meshwork, or shunting the aqueous humor to the suprachoroidal space have been approved undergoing clinical assessment within clinical trials. Currently, other devices under evaluation are showing promising results. Although these methods will increase the options available for glaucoma surgeons, it is unclear if they could replace the present standard surgeries, such as trabeculectomy, deep sclerectomy, and glaucoma drainage devices. Moreover, the standard procedures are continuously modified in different ways to become safer and more effective. In this issue L. Choritz et al. investigate whether increased concentrations of endothelin-1 in the aqueous humor samples of glaucoma patients influenced wound healing and bleb fibrosis after standard trabeculectomy with mitomycin C. Endothelin-1 is a potent vasoconstrictor produced in the eye by the ciliary epithelium and to be released into the aqueous humor. It has been implicated in the pathophysiology of glaucoma. Endothelin-1 is believed to be involved in the regulation of intraocular pressure (IOP) via effects on the contractility of ciliary muscle and trabecular meshwork... 000070676 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000070676 590__ $$a1.712$$b2016 000070676 591__ $$aOPHTHALMOLOGY$$b35 / 59 = 0.593$$c2016$$dQ3$$eT2 000070676 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b84 / 128 = 0.656$$c2016$$dQ3$$eT2 000070676 592__ $$a0.812$$b2016 000070676 593__ $$aOphthalmology$$c2016$$dQ2 000070676 655_4 $$ainfo:eu-repo/semantics/other$$vinfo:eu-repo/semantics/publishedVersion 000070676 700__ $$aMelamed, S. 000070676 700__ $$0(orcid)0000-0002-2914-2593$$aFerreras, A.$$uUniversidad de Zaragoza 000070676 700__ $$aMarchini, G. 000070676 700__ $$aCosta, V.P. 000070676 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología 000070676 773__ $$g2016, 5856075 (2016), [2 pp]$$pJ. Ophthalmol.$$tJournal of Ophthalmology$$x2090-004X 000070676 8564_ $$s1199477$$uhttps://zaguan.unizar.es/record/70676/files/texto_completo.pdf$$yVersión publicada 000070676 8564_ $$s100658$$uhttps://zaguan.unizar.es/record/70676/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000070676 909CO $$ooai:zaguan.unizar.es:70676$$particulos$$pdriver 000070676 951__ $$a2020-02-21-13:33:54 000070676 980__ $$aARTICLE