Intramuscular transplantation of bone marrow cells prolongs the lifespan of SOD1G93A mice and modulates expression of prognosis biomarkers of the disease
Resumen: Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive muscle weakness, paralysis and death. There is no effective treatment for ALS and stem cell therapy has arisen as a potential therapeutic approach.
Methods: SOD1 mutant mice were used to study the potential neurotrophic effect of bone marrow cells grafted into quadriceps femoris muscle.
Results: Bone marrow intramuscular transplants resulted in increased longevity with improved motor function and decreased motoneuron degeneration in the spinal cord. Moreover, the increment of the glial-derived neurotrophic factor and neurotrophin 4 observed in the grafted muscles suggests that this partial neuroprotective effect is mediated by neurotrophic factor release at the neuromuscular junction level. Finally, certain neurodegeneration and muscle disease-specific markers, which are altered in the SOD1G93A mutant mouse and may serve as molecular biomarkers for the early detection of ALS in patients, have been studied with encouraging results.
Conclusions: This work demonstrates that stem cell transplantation in the muscle prolonged the lifespan, increased motoneuron survival and slowed disease progression, which was also assessed by genetic expression analysis.

Idioma: Inglés
DOI: 10.1186/s13287-018-0843-z
Año: 2018
Publicado en: STEM CELL RESEARCH & THERAPY 9, 1 (2018), 90 [12 pp]
ISSN: 1757-6512

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RD16-001-0010
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SEV-2013-0317
Tipo y forma: Article (Published version)
Área (Departamento): Genética (Departamento de Anatomía, Embriología y Genética Animal)

Creative Commons You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.


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