000069712 001__ 69712
000069712 005__ 20190709135611.0
000069712 0247_ $$2doi$$a10.1039/c7ra08359a
000069712 0248_ $$2sideral$$a104733
000069712 037__ $$aART-2017-104733
000069712 041__ $$aeng
000069712 100__ $$aRegiel-Futyra, A.
000069712 245__ $$aDevelopment of noncytotoxic silver-chitosan nanocomposites for efficient control of biofilm forming microbes
000069712 260__ $$c2017
000069712 5060_ $$aAccess copy available to the general public$$fUnrestricted
000069712 5203_ $$aSevere bacterial and fungal infections have become a major clinical and public health concern. Nowadays, additional efforts are needed to develop effective antimicrobial materials that are not harmful to human cells. This work describes the synthesis and characterization of chitosan-ascorbic acid-silver nanocomposites as films exhibiting high antimicrobial activity and non-cytotoxicity towards human cells. The reductive and stabilizing activity of both the biocompatible polymer chitosan and ascorbic acid were used in the synthesis of silver nanoparticles (AgNPs). Herein, we propose an improved composite synthesis based on medium average molecular weight chitosan with a high deacetylation degree, that together with ascorbic acid gave films with a uniform distribution of small AgNPs (<10 nm) exhibiting high antimicrobial activity against biofilm forming bacterial and fungal strains of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans. At the same time, the resulting solid nanocomposites showed, at the same doses, reduced or totally excluded cytotoxicity on mammalian somatic and tumoral cells. Data obtained in the present study suggest that adequately designed chitosan-silver nanocomposites are powerful and promising materials for reducing pathogenic microorganism-associated infections without harmful effects towards mammalian cells.
000069712 536__ $$9info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
000069712 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000069712 590__ $$a2.936$$b2017
000069712 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b71 / 171 = 0.415$$c2017$$dQ2$$eT2
000069712 592__ $$a0.863$$b2017
000069712 593__ $$aChemistry (miscellaneous)$$c2017$$dQ1
000069712 593__ $$aChemical Engineering (miscellaneous)$$c2017$$dQ1
000069712 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000069712 700__ $$aKus-Liskiewicz, M.
000069712 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, V.$$uUniversidad de Zaragoza
000069712 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta, S.$$uUniversidad de Zaragoza
000069712 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000069712 700__ $$aKyziol, A.
000069712 700__ $$aStochel, G.
000069712 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000069712 773__ $$g7, 83 (2017), 52398-52413$$pRSC ADVANCES$$tRSC Advances$$x2046-2069
000069712 8564_ $$s737689$$uhttps://zaguan.unizar.es/record/69712/files/texto_completo.pdf$$yVersión publicada
000069712 8564_ $$s117267$$uhttps://zaguan.unizar.es/record/69712/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000069712 909CO $$ooai:zaguan.unizar.es:69712$$particulos$$pdriver
000069712 951__ $$a2019-07-09-12:22:42
000069712 980__ $$aARTICLE