000069458 001__ 69458
000069458 005__ 20191127155457.0
000069458 0247_ $$2doi$$a10.1371/journal.pone.0191977
000069458 0248_ $$2sideral$$a104589
000069458 037__ $$aART-2018-104589
000069458 041__ $$aeng
000069458 100__ $$aAbadia, B.
000069458 245__ $$aChoroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes
000069458 260__ $$c2018
000069458 5060_ $$aAccess copy available to the general public$$fUnrestricted
000069458 5203_ $$aObjective To compare choroidal thickness between patients with type 2 diabetes (T2D) and healthy controls measured using swept-source optical coherence tomography (SS-OCT). Methods The sample comprised 157 eyes of 94 T2D patients, 48 eyes of which had diabetic macular edema (DME), and 71 normal eyes of 38 healthy patients. Subfoveal (SF) choroidal thickness, and choroidal thickness at 500-µm intervals up to 2500 µm nasal and temporal from the fovea were measured using the SS-OCT. Choroidal thicknesses were compared between groups using Student’s t-test. Additionally, Pearson correlations were calculated between diabetes duration, glycosylated hemoglobin (HbA1c) levels, and choroidal thickness. Results Mean diabetes duration was 16.6±9.5 years, while mean glycosylated hemoglobin was 7.7 ±1.3%. Overall, the choroid was significantly thinner in T2D patients. Individuals with DME had reduced choroidal thickness in all measurements, except at 2000 and 2500-µm nasal positions, compared to healthy controls. There was a moderate correlation between choroidal thickness and HbA1c levels in DME patients (SF: r = 0.342; p = 0.017). Diabetes duration did not correlate significantly with choroidal thickness. Conclusion SS-OCT measurements revealed that the choroid was significantly thinner in T2D patients, moderate non-proliferative diabetic retinopathy patients, and DME patients than in healthy individuals. Further studies are needed to clarify the effect of diabetes on this layer and the relationship between choroidal thickness and DME.
000069458 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000069458 590__ $$a2.776$$b2018
000069458 591__ $$aMULTIDISCIPLINARY SCIENCES$$b23 / 69 = 0.333$$c2018$$dQ2$$eT2
000069458 592__ $$a1.1$$b2018
000069458 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2018$$dQ1
000069458 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000069458 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2018$$dQ1
000069458 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000069458 700__ $$aSuñen, I.
000069458 700__ $$0(orcid)0000-0002-6202-2382$$aCalvo, P.$$uUniversidad de Zaragoza
000069458 700__ $$aBartol, F.
000069458 700__ $$aVerdes, G.
000069458 700__ $$0(orcid)0000-0002-2914-2593$$aFerreras, A.$$uUniversidad de Zaragoza
000069458 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000069458 773__ $$g13, 2 (2018), e0191977[11 pp]$$pPLoS One$$tPloS one$$x1932-6203
000069458 8564_ $$s368254$$uhttps://zaguan.unizar.es/record/69458/files/texto_completo.pdf$$yVersión publicada
000069458 8564_ $$s74957$$uhttps://zaguan.unizar.es/record/69458/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000069458 909CO $$ooai:zaguan.unizar.es:69458$$particulos$$pdriver
000069458 951__ $$a2019-11-27-15:48:27
000069458 980__ $$aARTICLE