Resumen: Background and aims Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. Methods and results A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-a), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. Results Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. Conclusions Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently. Idioma: Inglés DOI: 10.1016/j.numecd.2017.10.004 Año: 2018 Publicado en: Nutrition, Metabolism and Cardiovascular Diseases 28, 1 (2018), 77-83 ISSN: 0939-4753 Factor impacto JCR: 3.34 (2018) Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 50 / 135 = 0.37 (2018) - Q2 - T2 Categ. JCR: NUTRITION & DIETETICS rank: 33 / 85 = 0.388 (2018) - Q2 - T2 Categ. JCR: ENDOCRINOLOGY & METABOLISM rank: 59 / 145 = 0.407 (2018) - Q2 - T2 Factor impacto SCIMAGO: 1.318 - Endocrinology, Diabetes and Metabolism (Q1) - Nutrition and Dietetics (Q1) - Medicine (miscellaneous) (Q1) - Cardiology and Cardiovascular Medicine (Q1)