000065584 001__ 65584
000065584 005__ 20180220133317.0
000065584 0247_ $$2doi$$a10.1016/j.numecd.2017.10.004
000065584 0248_ $$2sideral$$a104236
000065584 037__ $$aART-2018-104236
000065584 041__ $$aeng
000065584 100__ $$0(orcid)0000-0003-2005-8229$$aGonzález-Gil, E.M.$$uUniversidad de Zaragoza
000065584 245__ $$aInflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study
000065584 260__ $$c2018
000065584 5060_ $$aAccess copy available to the general public$$fUnrestricted
000065584 5203_ $$aBackground and aims Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. Methods and results A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-a), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. Results Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. Conclusions Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently.
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000065584 700__ $$aCadenas-Sanchez, C.
000065584 700__ $$0(orcid)0000-0001-9069-2167$$aSantabárbara, J.$$uUniversidad de Zaragoza
000065584 700__ $$0(orcid)0000-0002-0409-4791$$aBueno-Lozano, G.$$uUniversidad de Zaragoza
000065584 700__ $$0(orcid)0000-0002-2219-3646$$aIglesia, I.
000065584 700__ $$aGonzález-Gross, M.
000065584 700__ $$aMolnar, D.
000065584 700__ $$aGottrand, F.
000065584 700__ $$aDe Henauw, S.
000065584 700__ $$aKafatos, A.
000065584 700__ $$aWidhalm, K.
000065584 700__ $$aManios, Y.
000065584 700__ $$aSiani, A.
000065584 700__ $$aAmaro-Gahete, F.
000065584 700__ $$0(orcid)0000-0002-3850-8235$$aRupérez A.I.$$uUniversidad de Zaragoza
000065584 700__ $$aCañada, D.
000065584 700__ $$aCensi, L.
000065584 700__ $$aKersting, M.
000065584 700__ $$aDallongeville, J.
000065584 700__ $$aMarcos, A.
000065584 700__ $$aOrtega, F.B.
000065584 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.A.$$uUniversidad de Zaragoza
000065584 700__ $$aMoreno, L.A.
000065584 700__ $$aGottrand, F.
000065584 700__ $$aDe Henauw, S.
000065584 700__ $$aGonzález-Gross, M.
000065584 700__ $$aGilbert, C.
000065584 700__ $$aKafatos, A.
000065584 700__ $$aLibersa, C.
000065584 700__ $$aCastelló, S.
000065584 700__ $$aKersting, M.
000065584 700__ $$aSjöstrom, M.
000065584 700__ $$aMolnár, D.
000065584 700__ $$aDallongeville, J.
000065584 700__ $$aHall, G.
000065584 700__ $$aMaes, L.
000065584 700__ $$aScalfi, L.
000065584 700__ $$aMeléndez, P.
000065584 700__ $$aFleta, J.
000065584 700__ $$aCasajús, J.A.
000065584 700__ $$aRodríguez, G.
000065584 700__ $$aTomás, C.
000065584 700__ $$aMesana, M.I.
000065584 700__ $$aVicente-Rodríguez, G.
000065584 700__ $$aVillarroya, A.
000065584 700__ $$aGil, C.M.
000065584 700__ $$aAra, I.
000065584 700__ $$aAlvira, J.F.
000065584 700__ $$aBueno, G.
000065584 700__ $$aLázaro, A.
000065584 700__ $$aBueno, O.
000065584 700__ $$aLeón, J.F.
000065584 700__ $$aGaragorri, J.M.
000065584 700__ $$aBueno, M.
000065584 700__ $$aLabayen, I.
000065584 700__ $$aIglesia, I.
000065584 700__ $$aBel Serrat, S.
000065584 700__ $$aGracia Marco, L.A.
000065584 700__ $$aMouratidou, T.
000065584 700__ $$aSantaliestra-Pasías, A.
000065584 700__ $$aGonzález-Gil, E.M.
000065584 700__ $$aDe Miguel-Etayo, P.
000065584 700__ $$aJulián Almárcegui, C.
000065584 700__ $$aMiguel-Berges, M.
000065584 700__ $$aIguacel, I.
000065584 700__ $$aMarcos, A.
000065584 700__ $$aWärnberg, J.
000065584 700__ $$aNova, E.
000065584 700__ $$aGómez, S.
000065584 700__ $$aDíaz, L.E.
000065584 700__ $$aRomeo, J.
000065584 700__ $$aVeses, A.
000065584 700__ $$aZapatera, B.
000065584 700__ $$aPozo, T.
000065584 700__ $$aMartínez, D.
000065584 700__ $$aBeghin, L.
000065584 700__ $$aGottrand, F.
000065584 700__ $$aIliescu, C.
000065584 700__ $$aVon Berlepsch, J.
000065584 700__ $$aSichert-Hellert, W.
000065584 700__ $$aKoeppen, E.
000065584 700__ $$aMolnar, D.
000065584 700__ $$aErhardt, E.
000065584 700__ $$aCsernus, K.
000065584 700__ $$aTörök, K.
000065584 700__ $$aBokor, S.
000065584 700__ $$aAngster
000065584 700__ $$aNagy, E.
000065584 700__ $$aKovács, O.
000065584 700__ $$aRépasi, J.
000065584 700__ $$aCodrington, C.
000065584 700__ $$aPlada, M.
000065584 700__ $$aPapadaki, A.
000065584 700__ $$aSarri, K.
000065584 700__ $$aViskadourou, A.
000065584 700__ $$aHatzis, C.
000065584 700__ $$aKiriakakis, M.
000065584 700__ $$aTsibinos, G.
000065584 700__ $$aVardavas, C.
000065584 700__ $$aSbokos, M.
000065584 700__ $$aProtoyeraki, E.
000065584 700__ $$aFasoulaki, M.
000065584 700__ $$aStehle, P.
000065584 700__ $$aPietrzik, K.
000065584 700__ $$aBreidenassel, C.
000065584 700__ $$aSpinneker, A.
000065584 700__ $$aAl-Tahan, J.
000065584 700__ $$aSegoviano, M.
000065584 700__ $$aBerchtold, A.
000065584 700__ $$aBierschbach, C.
000065584 700__ $$aBlatzheim, E.
000065584 700__ $$aSchuch, A.
000065584 700__ $$aPickert, P.
000065584 700__ $$aCastillo, M.J.
000065584 700__ $$aGutiérrez, Á.
000065584 700__ $$aOrtega, F.B.
000065584 700__ $$aRuiz, J.R.
000065584 700__ $$aArtero, E.G.
000065584 700__ $$aEspaña, V.
000065584 700__ $$aJiménez-Pavón, D.
000065584 700__ $$aChillón, P.
000065584 700__ $$aSánchez-Muñoz, C.
000065584 700__ $$aCuenca, M.
000065584 700__ $$aArcella, D.
000065584 700__ $$aAzzini, E.
000065584 700__ $$aBarrison, E.
000065584 700__ $$aBevilacqua, N.
000065584 700__ $$aBuonocore, P.
000065584 700__ $$aCatasta, G.
000065584 700__ $$aCensi, L.
000065584 700__ $$aCiarapica, D.
000065584 700__ $$aD''Acapito, P.
000065584 700__ $$aFerrari, M.
000065584 700__ $$aGalfo, M.
000065584 700__ $$aLe Donne, C.
000065584 700__ $$aLeclercq, C.
000065584 700__ $$aMaiani, G.
000065584 700__ $$aMauro, B.
000065584 700__ $$aMistura, L.
000065584 700__ $$aPasquali, A.
000065584 700__ $$aPiccinelli, R.
000065584 700__ $$aPolito, A.
000065584 700__ $$aRoccaldo, R.
000065584 700__ $$aSpada, R.
000065584 700__ $$aSette, S.
000065584 700__ $$aZaccaria, M.
000065584 700__ $$aVitaglione, P.
000065584 700__ $$aMontagnese, C.
000065584 700__ $$aDe Bourdeaudhuij, I.
000065584 700__ $$aDe Vriendt, T.
000065584 700__ $$aMatthys, C.
000065584 700__ $$aVereecken, C.
000065584 700__ $$ade Maeyer, M.
000065584 700__ $$aOttevaere, C.
000065584 700__ $$aHuybrechts, I.
000065584 700__ $$aWidhalm, K.
000065584 700__ $$aPhillipp, K.
000065584 700__ $$aDietrich, S.
000065584 700__ $$aWidhalm, K.
000065584 700__ $$aPhillipp, K.
000065584 700__ $$aDietrich, S.
000065584 700__ $$aManios, Y.
000065584 700__ $$aGrammatikaki, E.
000065584 700__ $$aBouloubasi, Z.
000065584 700__ $$aCook, T.L.
000065584 700__ $$aEleutheriou, S.
000065584 700__ $$aConsta, O.
000065584 700__ $$aMoschonis, G.
000065584 700__ $$aKatsaroli, I.
000065584 700__ $$aKraniou, G.
000065584 700__ $$aPapoutsou, S.
000065584 700__ $$aKeke, D.
000065584 700__ $$aPetraki, I.
000065584 700__ $$aBellou, E.
000065584 700__ $$aTanagra, S.
000065584 700__ $$aKallianoti, K.
000065584 700__ $$aArgyropoulou, D.
000065584 700__ $$aTsikrika, S.
000065584 700__ $$aKaraiskos, C.
000065584 700__ $$aMeirhaeghe, A.
000065584 700__ $$aMeirhaeghe, A.
000065584 700__ $$aOrtega, F.B.
000065584 700__ $$aHagströmer, M.
000065584 700__ $$aWennlöf, A.H.
000065584 700__ $$aHallström, L.
000065584 700__ $$aPatterson, E.
000065584 700__ $$aKwak, L.
000065584 700__ $$aRizzo, N.
000065584 700__ $$aSánchez-Molero, J.
000065584 700__ $$aPicó, E.
000065584 700__ $$aNavarro, M.
000065584 700__ $$aViadel, B.
000065584 700__ $$aCarreres, J.E.
000065584 700__ $$aMerino, G.
000065584 700__ $$aSanjuán, R.
000065584 700__ $$aLorente, M.
000065584 700__ $$aSánchez, M.J.
000065584 700__ $$aThomas, S.
000065584 700__ $$aAllchurch, E.
000065584 700__ $$aBurgess, P.
000065584 700__ $$aAstrom, A.
000065584 700__ $$aSverkén, A.
000065584 700__ $$aBroberg, A.
000065584 700__ $$aMasson, A.
000065584 700__ $$aLehoux, C.
000065584 700__ $$aBrabant, P.
000065584 700__ $$aPate, P.
000065584 700__ $$aFontaine, L.
000065584 700__ $$aSebok, A.
000065584 700__ $$aKuti, T.
000065584 700__ $$aHegyi, A.
000065584 700__ $$aMaldonado, C.
000065584 700__ $$aMoreno, L.A.
000065584 700__ $$aLlorente, A.
000065584 700__ $$aGarcía, E.
000065584 700__ $$avon Fircks, H.
000065584 700__ $$aHallberg, M.L.
000065584 700__ $$aMesserer, M.
000065584 700__ $$aLarsson, M.
000065584 700__ $$aFredriksson, H.
000065584 700__ $$aAdamsson, V.
000065584 700__ $$aBörjesson, I.
000065584 700__ $$aFernández, L.
000065584 700__ $$aSmillie, L.
000065584 700__ $$aWills, J.
000065584 700__ $$aPedrero-Chamizo, R.
000065584 700__ $$aMeléndez, A.
000065584 700__ $$aValtueña, J.
000065584 700__ $$aAlbers, U.
000065584 700__ $$aBenito, P.J.
000065584 700__ $$aGómez Lorente, J.J.
000065584 700__ $$aCañada, D.
000065584 700__ $$aUrzanqui, A.
000065584 700__ $$aTorres, R.M.
000065584 700__ $$aNavarro, P.
000065584 7102_ $$11010$$2670$$aUniversidad de Zaragoza$$bDepartamento de Pediatría, Radiología y Medicina Física$$cPediatría
000065584 7102_ $$11008$$2615$$aUniversidad de Zaragoza$$bDepartamento de Microbiología, Medicina Preventiva y Salud Pública$$cMedicina Preventiva y Salud Pública
000065584 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDepartamento de Fisiatría y Enfermería$$cEnfermería
000065584 773__ $$g28, 1 (2018), 77-83$$pNMCD, Nutr. Metab. Cardiovasc. Dis.$$tNUTRITION METABOLISM AND CARDIOVASCULAR DISEASES$$x0939-4753
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