000065303 001__ 65303
000065303 005__ 20190709135655.0
000065303 0247_ $$2doi$$a10.1002/cam4.1217
000065303 0248_ $$2sideral$$a104300
000065303 037__ $$aART-2017-104300
000065303 041__ $$aeng
000065303 100__ $$aJiménez-Ubieto, A.
000065303 245__ $$aProgression-free survival at 2 years post-autologous transplant: a surrogate end point for overall survival in follicular lymphoma
000065303 260__ $$c2017
000065303 5060_ $$aAccess copy available to the general public$$fUnrestricted
000065303 5203_ $$aOverall survival (OS) is the gold-standard end point for studies evaluating autologous stem cell transplantation (ASCT) in follicular lymphoma (FL), but assessment may be elusive due to the lengthy disease course. We analyzed the validity of two earlier end points, proposed in the setting of first-line chemo-/immunotherapy, as surrogates for OS—progression-free survival (PFS) status at 24 months (PFS24) and complete response at 30 months (CR30) post-ASCT. We also have investigated the clinical features of patients with early progression after ASCT. Data were available for 626 chemosensitive FL patients who received ASCT between 1989 and 2007. Median follow-up was 12.2 years from ASCT. In the PFS24 analysis, 153 (24%) patients progressed within 24 months and 447 were alive and progression-free at 24 months post-ASCT (26 who died without disease progressions within 24 months were excluded). Early progression was associated with shorter OS (hazard ratio [HR], 6.8; P = 0.00001). In the subgroup of patients who received an ASCT in the setting or relapse after being exposed to rituximab, the HR was 11.3 (95% CI, 3.9–30.2; P < 0.00001). In the CR30 analysis, 183 of 596 (31%) response-evaluable patients progressed/died with 30 months post-ASCT. The absence of CR30 was associated with shorter OS (HR, 7.8; P < 0.00001), including in patients with prior rituximab (HR, 8.2). PFS24 and CR30 post-ASCT are associated with poor outcomes and should be primary end points. Further research is needed to identify this population to be offered alternative treatments.
000065303 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000065303 590__ $$a3.202$$b2017
000065303 591__ $$aONCOLOGY$$b110 / 222 = 0.495$$c2017$$dQ2$$eT2
000065303 592__ $$a1.47$$b2017
000065303 593__ $$aOncology$$c2017$$dQ1
000065303 593__ $$aRadiology, Nuclear Medicine and Imaging$$c2017$$dQ1
000065303 593__ $$aCancer Research$$c2017$$dQ2
000065303 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000065303 700__ $$aGrande, C.
000065303 700__ $$aCaballero, D.
000065303 700__ $$aYáñez, L.
000065303 700__ $$aNovelli, S.
000065303 700__ $$aHernández, M.T.
000065303 700__ $$aManzanares, M.
000065303 700__ $$aArranz, R.
000065303 700__ $$aFerreiro, J.J.
000065303 700__ $$aBobillo, S.
000065303 700__ $$aMercadal, S.
000065303 700__ $$aGalego, A.
000065303 700__ $$aJiménez, J.L.
000065303 700__ $$aMoraleda, J.M.
000065303 700__ $$aVallejo, C.
000065303 700__ $$aAlbo, C.
000065303 700__ $$aPérez, E.
000065303 700__ $$aMarrero, C.
000065303 700__ $$aMagnano, L.
000065303 700__ $$0(orcid)0000-0001-8515-3599$$aPalomera, L.$$uUniversidad de Zaragoza
000065303 700__ $$aJarque, I.
000065303 700__ $$aCoria, E.
000065303 700__ $$aRodriguez, A.
000065303 700__ $$aMartín, A.
000065303 700__ $$aLópez-Guillermo, A.
000065303 700__ $$aSalar, A.
000065303 700__ $$aLahuerta, J.J.
000065303 700__ $$athe, GELTAMO, (Grupo, Espanol, de, Linfomas, y, Trasplantes, de, Medula, Osea), cooperative, study, group
000065303 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000065303 773__ $$g6, 12 (2017), 2766-2774$$pCancer med.$$tCancer medicine$$x2045-7634
000065303 8564_ $$s140228$$uhttps://zaguan.unizar.es/record/65303/files/texto_completo.pdf$$yVersión publicada
000065303 8564_ $$s88377$$uhttps://zaguan.unizar.es/record/65303/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000065303 909CO $$ooai:zaguan.unizar.es:65303$$particulos$$pdriver
000065303 951__ $$a2019-07-09-12:45:43
000065303 980__ $$aARTICLE