000065302 001__ 65302
000065302 005__ 20190709135655.0
000065302 0247_ $$2doi$$a10.1038/s41467-017-02292-8
000065302 0248_ $$2sideral$$a104299
000065302 037__ $$aART-2017-104299
000065302 041__ $$aeng
000065302 100__ $$aGordon, S.P.
000065302 245__ $$aExtensive gene content variation in the Brachypodium distachyon pan-genome correlates with population structure
000065302 260__ $$c2017
000065302 5060_ $$aAccess copy available to the general public$$fUnrestricted
000065302 5203_ $$aWhile prokaryotic pan-genomes have been shown to contain many more genes than any individual organism, the prevalence and functional significance of differentially present genes in eukaryotes remains poorly understood. Whole-genome de novo assembly and annotation of 54 lines of the grass Brachypodium distachyon yield a pan-genome containing nearly twice the number of genes found in any individual genome. Genes present in all lines are enriched for essential biological functions, while genes present in only some lines are enriched for conditionally beneficial functions (e.g., defense and development), display faster evolutionary rates, lie closer to transposable elements and are less likely to be syntenic with orthologous genes in other grasses. Our data suggest that differentially present genes contribute substantially to phenotypic variation within a eukaryote species, these genes have a major influence in population genetics, and transposable elements play a key role in pan-genome evolution.
000065302 536__ $$9info:eu-repo/grantAgreement/ES/DGA/Bioflora$$9info:eu-repo/grantAgreement/ES/DGA/GA-LC-059-2011$$9info:eu-repo/grantAgreement/ES/MINECO/AGL2013-48756-R$$9info:eu-repo/grantAgreement/ES/MINECO/CGL2012-39953-C02-01$$9info:eu-repo/grantAgreement/ES/MINECO/CGL2016-79790-P$$9info:eu-repo/grantAgreement/ES/MINECO/CSIC13-4E-2490
000065302 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000065302 590__ $$a12.353$$b2017
000065302 591__ $$aMULTIDISCIPLINARY SCIENCES$$b3 / 64 = 0.047$$c2017$$dQ1$$eT1
000065302 592__ $$a6.582$$b2017
000065302 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2017$$dQ1
000065302 593__ $$aPhysics and Astronomy (miscellaneous)$$c2017$$dQ1
000065302 593__ $$aChemistry (miscellaneous)$$c2017$$dQ1
000065302 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000065302 700__ $$0(orcid)0000-0002-5462-907X$$aContreras-Moreira, B.$$uUniversidad de Zaragoza
000065302 700__ $$aWoods, D.P.
000065302 700__ $$aDes Marais, D.L.
000065302 700__ $$aBurgess, D.
000065302 700__ $$aShu, S.
000065302 700__ $$aStritt, C.
000065302 700__ $$aRoulin, A.C.
000065302 700__ $$aSchackwitz, W.
000065302 700__ $$aTyler, L.
000065302 700__ $$aMartin, J.
000065302 700__ $$aLipzen, A.
000065302 700__ $$aDochy, N.
000065302 700__ $$aPhillips, J.
000065302 700__ $$aBarry, K.
000065302 700__ $$aGeuten, K.
000065302 700__ $$aBudak, H.
000065302 700__ $$aJuenger, T.E.
000065302 700__ $$aAmasino, R.
000065302 700__ $$aCaicedo, A.L.
000065302 700__ $$aGoodstein, D.
000065302 700__ $$aDavidson, P.
000065302 700__ $$aMur, L.A.J.
000065302 700__ $$aFigueroa, M.
000065302 700__ $$aFreeling, M.
000065302 700__ $$0(orcid)0000-0001-7793-5259$$aCatalan, P.$$uUniversidad de Zaragoza
000065302 700__ $$aVogel, J.P.
000065302 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000065302 7102_ $$15011$$2063$$aUniversidad de Zaragoza$$bDpto. CC.Agrar.y Medio Natural$$cÁrea Botánica
000065302 773__ $$g8, 1 (2017), 2184 [13 pp]$$pNATURE COMMUNICATIONS$$tNature Communications$$x2041-1723
000065302 8564_ $$s2395043$$uhttps://zaguan.unizar.es/record/65302/files/texto_completo.pdf$$yVersión publicada
000065302 8564_ $$s82682$$uhttps://zaguan.unizar.es/record/65302/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000065302 909CO $$ooai:zaguan.unizar.es:65302$$particulos$$pdriver
000065302 951__ $$a2019-07-09-12:45:41
000065302 980__ $$aARTICLE