000065286 001__ 65286
000065286 005__ 20190709135647.0
000065286 0247_ $$2doi$$a10.3389/fneur.2017.00684
000065286 0248_ $$2sideral$$a104271
000065286 037__ $$aART-2017-104271
000065286 041__ $$aeng
000065286 100__ $$0(orcid)0000-0001-9876-5850$$aAscaso, F.J.$$uUniversidad de Zaragoza
000065286 245__ $$aOptical coherence tomography in patients with chronic migraine: Literature review and update
000065286 260__ $$c2017
000065286 5060_ $$aAccess copy available to the general public$$fUnrestricted
000065286 5203_ $$aMigraine is a chronic disease characterized by unilateral, pulsating, and often moderate-to-severe recurrent episodes of headache with nausea and vomiting. It affects approximately 15% of the general population, yet the underlying pathophysiological mechanisms are not fully understood. Optical coherence tomography (OCT) is a safe and reproducible diagnostic technique that utilizes infrared wavelengths and has a sensitivity of 8-10 µm. It can be used to measure thinning of the retinal nerve fiber layer (RNFL) in some neurological disorders. Although ophthalmologists are often the first specialists to examine patients with migraine, few studies have addressed the involvement of the optic nerve and retino-choroidal structures in this group. We reviewed the literature on the etiological and pathological mechanisms of migraine and the relationship between recurrent constriction of cerebral and retrobulbar vessels and ischemic damage to the optic nerve, retina, and choroid. We also assessed the role of OCT for measuring peripapillary RNFL thickness and macular and choroidal changes in migraine patients. There is considerable evidence of cerebral and retrobulbar vascular involvement in the etiology of migraine. Transitory and recurrent constriction of the retinal and ciliary arteries may cause ischemic damage to the optic nerve, retina, and choroid in patients with migraine. OCT to assess the thickness of the peripapillary RNFL, macula, and choroid might increase our understanding of the pathophysiology of migraine and facilitate diagnosis of retino-choroidal compromise and follow-up of therapy in migraine patients. Future studies should determine the usefulness of OCT findings as a biomarker of migraine.
000065286 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000065286 590__ $$a3.508$$b2017
000065286 591__ $$aNEUROSCIENCES$$b88 / 261 = 0.337$$c2017$$dQ2$$eT2
000065286 591__ $$aCLINICAL NEUROLOGY$$b54 / 197 = 0.274$$c2017$$dQ2$$eT1
000065286 592__ $$a1.402$$b2017
000065286 593__ $$aNeurology (clinical)$$c2017$$dQ1
000065286 593__ $$aNeurology$$c2017$$dQ2
000065286 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000065286 700__ $$aMarco, S.
000065286 700__ $$aMateo, J.
000065286 700__ $$aMartínez, M.
000065286 700__ $$aEsteban, O.
000065286 700__ $$aGrzybowski, A.
000065286 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000065286 773__ $$g8, DEC (2017), 684 [7 pp]$$pFront. neurol.$$tFrontiers in Neurology$$x1664-2295
000065286 8564_ $$s215624$$uhttps://zaguan.unizar.es/record/65286/files/texto_completo.pdf$$yVersión publicada
000065286 8564_ $$s97425$$uhttps://zaguan.unizar.es/record/65286/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000065286 909CO $$ooai:zaguan.unizar.es:65286$$particulos$$pdriver
000065286 951__ $$a2019-07-09-12:42:00
000065286 980__ $$aARTICLE