000064434 001__ 64434
000064434 005__ 20180123110900.0
000064434 0247_ $$2doi$$a10.18632/oncotarget.16261
000064434 0248_ $$2sideral$$a98658
000064434 037__ $$aART-2017-98658
000064434 041__ $$aeng
000064434 100__ $$aCarrera-Lasfuentes, Patricia
000064434 245__ $$aRelevance of DNA repair gene polymorphisms to gastric cancer risk and phenotype
000064434 260__ $$c2017
000064434 5060_ $$aAccess copy available to the general public$$fUnrestricted
000064434 5203_ $$aVariations in DNA repair genes have been reported as key factors in gastric cancer (GC) susceptibility but results among studies are inconsistent. We aimed to assess the relevance of DNA repair gene polymorphisms and environmental factors to GC risk and phenotype in a Caucasian population in Spain. Genomic DNA from 603 patients with primary GC and 603 healthy controls was typed for 123 single nucleotide polymorphisms in DNA repair genes using the Illumina platform. Helicobacter pylori infection with CagA strains (odds ratio (OR): 1.99; 95% confidence interval (CI): 1.55–2.54), tobacco smoking (OR: 1.77; 95% CI: 1.22–2.57), and family history of GC (OR: 2.87; 95% CI: 1.85–4.45) were identified as independent risk factors for GC. By contrast, the TP53 rs9894946A (OR: 0.73; 95% CI: 0.56–0.96), TP53 rs1042522C (OR: 0.76; 95% CI: 0.56–0.96), and BRIP1 rs4986764T (OR: 0.55; 95% CI: 0.38–0.78) variants were associated with lower GC risk. Significant associations with specific anatomopathological GC subtypes were also observed, most notably in the ERCC4 gene with the rs1799801C, rs2238463G, and rs3136038T variants being inversely associated with cardia GC risk. Moreover, the XRCC3 rs861528 allele A was significantly increased in the patient subgroup with diffuse GC (OR: 1.75; 95% CI: 1.30–2.37). Our data show that specific TP53, BRIP1, ERCC4, and XRCC3 polymorphisms are relevant in susceptibility to GC risk and specific subtypes in Caucasians.
000064434 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/FIS/PI09-00213$$9info:eu-repo/grantAgreement/ES/MINECO/FIS/PI15-00331
000064434 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000064434 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000064434 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, Angel$$uUniversidad de Zaragoza
000064434 700__ $$aBujanda, Luis
000064434 700__ $$aStrunk, Mark
000064434 700__ $$aQuintero, Enrique
000064434 700__ $$aSantolaria, Santos
000064434 700__ $$0(orcid)0000-0001-5134-1006$$aBenito, Rafael$$uUniversidad de Zaragoza
000064434 700__ $$0(orcid)0000-0002-8678-4680$$aSopeña, Federico$$uUniversidad de Zaragoza
000064434 700__ $$0(orcid)0000-0001-5813-3445$$aPiazuelo, Elena$$uUniversidad de Zaragoza
000064434 700__ $$aThomson, Concha
000064434 700__ $$aPérez-Aisa, Angeles
000064434 700__ $$aNicolás-Pérez, David
000064434 700__ $$aHijona, Elizabeth
000064434 700__ $$aEspinel, Jesús
000064434 700__ $$aRafael Campo
000064434 700__ $$aMarisa Manzano
000064434 700__ $$aFernando Geijo
000064434 700__ $$aMaría Pellise
000064434 700__ $$aManuel Zaballa
000064434 700__ $$aGonzález-Huix, Ferrán
000064434 700__ $$aEspinós, Jorge
000064434 700__ $$aTitó, Llúcia
000064434 700__ $$aBarranco, Luis
000064434 700__ $$aD’Amato, Mauro
000064434 700__ $$aGarcía-González, María Asunción
000064434 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDepartamento de Medicina, Psiquiatría y Dermatología$$cMedicina
000064434 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDepartamento de Farmacología y Fisiología$$cFisiología
000064434 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDepartamento de Microbiología, Medicina Preventiva y Salud Pública$$cMicrobiología
000064434 773__ $$g8, 22 (2017), 35848-35862$$pONCOTARGET$$tONCOTARGET$$x1949-2553
000064434 8564_ $$s4510288$$uhttp://zaguan.unizar.es/record/64434/files/texto_completo.pdf$$yVersión publicada
000064434 8564_ $$s112034$$uhttp://zaguan.unizar.es/record/64434/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000064434 909CO $$ooai:zaguan.unizar.es:64434$$particulos$$pdriver
000064434 951__ $$a2018-01-22-14:55:45
000064434 980__ $$aARTICLE