000063303 001__ 63303
000063303 005__ 20180518103753.0
000063303 0247_ $$2doi$$a10.1371/journal.pone.0072091
000063303 0248_ $$2sideral$$a82821
000063303 037__ $$aART-2013-82821
000063303 041__ $$aeng
000063303 100__ $$aPicelli, S.
000063303 245__ $$aMeta-Analysis of Mismatch Repair Polymorphisms within the Cogent Consortium for Colorectal Cancer Susceptibility
000063303 260__ $$c2013
000063303 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063303 5203_ $$aIn the last four years, Genome-Wide Association Studies (GWAS) have identified sixteen low-penetrance polymorphisms on fourteen different loci associated with colorectal cancer (CRC). Due to the low risks conferred by known common variants, most of the 35% broad-sense heritability estimated by twin studies remains unexplained. Recently our group performed a case-control study for eight Single Nucleotide Polymorphisms (SNPs) in 4 CRC genes. The present investigation is a follow-up of that study. We have genotyped six SNPs that showed a positive association and carried out a meta-analysis based on eight additional studies comprising in total more than 8000 cases and 6000 controls. The estimated recessive odds ratio for one of the SNPs, rs3219489 (MUTYH Q338H), decreased from 1.52 in the original Swedish study, to 1.18 in the Swedish replication, and to 1.08 in the initial meta-analysis. Since the corresponding summary probability value was 0.06, we decided to retrieve additional information for this polymorphism. The incorporation of six further studies resulted in around 13000 cases and 13000 controls. The newly updated OR was 1.03. The results from the present large, multicenter study illustrate the possibility of decreasing effect sizes with increasing samples sizes. Phenotypic heterogeneity, differential environmental exposures, and population specific linkage disequilibrium patterns may explain the observed difference of genetic effects between Sweden and the other investigated cohorts.
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000063303 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063303 590__ $$a3.534$$b2013
000063303 591__ $$aMULTIDISCIPLINARY SCIENCES$$b8 / 56 = 0.143$$c2013$$dQ1$$eT1
000063303 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000063303 700__ $$aLorenzo Bermejo, J.
000063303 700__ $$aChang Claude, J.
000063303 700__ $$aHoffmeister, M.
000063303 700__ $$aFernández Rozadilla, C.
000063303 700__ $$aCarracedo, A.
000063303 700__ $$aCastells, A.
000063303 700__ $$aCastellví Bel, S.
000063303 700__ $$aJuan, D.M.
000063303 700__ $$aRaquel, M.
000063303 700__ $$aMarisa, M.
000063303 700__ $$aFrancisco, C.
000063303 700__ $$aJose, D.
000063303 700__ $$aCarolina, I.
000063303 700__ $$aGuadalupe, L.
000063303 700__ $$aAlberto, I.
000063303 700__ $$aAntoni, C.
000063303 700__ $$aVirgínia, P.
000063303 700__ $$aSergi, C.B.
000063303 700__ $$aBalaguer, F.
000063303 700__ $$aVictoria, G.
000063303 700__ $$aTeresa, O.
000063303 700__ $$aMaría Dolores, G.
000063303 700__ $$aMaria, P.
000063303 700__ $$aAnna, S.
000063303 700__ $$aLeticia, M.
000063303 700__ $$aMiriam, C.
000063303 700__ $$aJosep, M.P.
000063303 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, A.$$uUniversidad de Zaragoza
000063303 700__ $$0(orcid)0000-0001-6522-6682$$aAlcedo, J.
000063303 700__ $$0(orcid)0000-0002-3869-8235$$aOrtego, F.J.$$uUniversidad de Zaragoza
000063303 700__ $$aJoaquin, C.
000063303 700__ $$aMa, S.D.
000063303 700__ $$aMercedes, S.
000063303 700__ $$aEloy, S.
000063303 700__ $$aMariano, V.
000063303 700__ $$aMontserrat, A.
000063303 700__ $$aAnna, A.
000063303 700__ $$aXavier, B.
000063303 700__ $$aMar, I.
000063303 700__ $$aAgustín, S.
000063303 700__ $$aFelipe, B.
000063303 700__ $$aGemma, N.
000063303 700__ $$aBeatriz, B.
000063303 700__ $$aDe Josep, M.
000063303 700__ $$aCristina, Á.
000063303 700__ $$aMarc, P.
000063303 700__ $$aLuis, B.
000063303 700__ $$aÁngel, C.
000063303 700__ $$aInés, G.
000063303 700__ $$aMikel, L.
000063303 700__ $$aCarlos, P.
000063303 700__ $$aMaría, d.M.R.
000063303 700__ $$aElisabeth, H.
000063303 700__ $$aJose, M.E.N.
000063303 700__ $$aJose, L.E.
000063303 700__ $$aArtemio, P.
000063303 700__ $$aRodrigo, J.
000063303 700__ $$aCristina, A.
000063303 700__ $$aLaura, S.
000063303 700__ $$aNuria, A.
000063303 700__ $$aEstefanía, R.
000063303 700__ $$aLucía, P.C.
000063303 700__ $$aJoaquim, R.
000063303 700__ $$aÁngel, S.
000063303 700__ $$aAnna, G.
000063303 700__ $$aJoan, S.
000063303 700__ $$aEduard, B.A.
000063303 700__ $$aJosefina, A.
000063303 700__ $$aRamon, B.
000063303 700__ $$aAna, M.G.
000063303 700__ $$aFernando, C.
000063303 700__ $$aAntonio, B.
000063303 700__ $$aEduardo, S.
000063303 700__ $$aFernando, G.
000063303 700__ $$aJaime, S.
000063303 700__ $$aAkiko, O.
000063303 700__ $$aMercedes, L.
000063303 700__ $$aEnrique, M.
000063303 700__ $$aJaime, C.
000063303 700__ $$aPilar, C.
000063303 700__ $$aMiguel, M.
000063303 700__ $$aJosé, A.G.
000063303 700__ $$aFrancisco, Q.
000063303 700__ $$aElisa, O.
000063303 700__ $$aJuan, C.
000063303 700__ $$aJaime, S.
000063303 700__ $$aAntoni, T.
000063303 700__ $$aEugenia, S.
000063303 700__ $$ade Ma, L.C.
000063303 700__ $$aAntoni, T.
000063303 700__ $$aJuan, C.
000063303 700__ $$aVicent, H.
000063303 700__ $$aXavier, L.
000063303 700__ $$aRosa, M.X.
000063303 700__ $$aMarta, P.
000063303 700__ $$aMercè, R.
000063303 700__ $$aAnna, R.
000063303 700__ $$aElisenda, P.
000063303 700__ $$aJosé, M.H.
000063303 700__ $$aMiquel, A.G.
000063303 700__ $$aFernando, F.B.
000063303 700__ $$aJosep, M.V.
000063303 700__ $$aAntonio, S.
000063303 700__ $$aJorge, E.
000063303 700__ $$aMontserrat, F.
000063303 700__ $$aMaria, E.
000063303 700__ $$aJosep, M.R.
000063303 700__ $$aCarmen, P.
000063303 700__ $$aJuan, B.
000063303 700__ $$aJoan, V.
000063303 700__ $$aEnrique, Q.
000063303 700__ $$aDavid, N.
000063303 700__ $$aAdolfo, P.
000063303 700__ $$aAntonio, M.
000063303 700__ $$aLidia, A.
000063303 700__ $$aVicente, P.
000063303 700__ $$aVirginia, P.
000063303 700__ $$aTeresa, S.
000063303 700__ $$aDolors, G.
000063303 700__ $$aEva, R.
000063303 700__ $$aTeresa, R.
000063303 700__ $$aMaria, P.
000063303 700__ $$aMa, M.C.
000063303 700__ $$aMarta, M.
000063303 700__ $$aLourdes, P.
000063303 700__ $$aDaniel, M.
000063303 700__ $$aÁngel, C.
000063303 700__ $$aClara, R.P.
000063303 700__ $$aCeres, F.R.
000063303 700__ $$aMa, M.C.
000063303 700__ $$aSabino, R.
000063303 700__ $$aLuis, R.
000063303 700__ $$aJavier, F.
000063303 700__ $$aJose, L.C.
000063303 700__ $$aLuis, C.
000063303 700__ $$aSusana, O.
000063303 700__ $$aFederico, B.
000063303 700__ $$aElena, P.
000063303 700__ $$aJosé, M.B.
000063303 700__ $$aGloria, C.
000063303 700__ $$aJuan, J.S.
000063303 700__ $$aAntonio, N.
000063303 700__ $$aNaccarati, A.
000063303 700__ $$aPardini, B.
000063303 700__ $$aVodickova, L.
000063303 700__ $$aMüller, H.
000063303 700__ $$aTalseth Palmer, B.A.
000063303 700__ $$aStibbard, G.
000063303 700__ $$aPeterlongo, P.
000063303 700__ $$aNici, C.
000063303 700__ $$aVeneroni, S.
000063303 700__ $$aLi, L.
000063303 700__ $$aCasey, G.
000063303 700__ $$aTenesa, A.
000063303 700__ $$aFarrington, S.M.
000063303 700__ $$aTomlinson, I.
000063303 700__ $$aMoreno, V.
000063303 700__ $$avan Wezel, T.
000063303 700__ $$aWijnen, J.
000063303 700__ $$aDunlop, M.
000063303 700__ $$aRadice, P.
000063303 700__ $$aScott, R.J.
000063303 700__ $$aVodicka, P.
000063303 700__ $$aRuiz Ponte, C.
000063303 700__ $$aBrenner, H.
000063303 700__ $$aBuch, S.
000063303 700__ $$aVölzke, H.
000063303 700__ $$aHampe, J.
000063303 700__ $$aSchafmayer, C.
000063303 700__ $$aLindblom, A.
000063303 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDepartamento de Medicina, Psiquiatría y Dermatología$$cMedicina
000063303 7102_ $$11000$$2020$$aUniversidad de Zaragoza$$bDepartamento de Anatomía Patológica, Medicina Legal y Forense y Toxicología$$cAnatomía Patológica
000063303 773__ $$g8, 9 (2013), e72091 [6 pp]$$pPLoS One$$tPLoS One$$x1932-6203
000063303 8564_ $$s176603$$uhttp://zaguan.unizar.es/record/63303/files/texto_completo.pdf$$yVersión publicada
000063303 8564_ $$s129590$$uhttp://zaguan.unizar.es/record/63303/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000063303 951__ $$a2018-05-18-10:36:32
000063303 980__ $$aARTICLE