000063282 001__ 63282
000063282 005__ 20171129112116.0
000063282 0247_ $$2doi$$a10.1039/c5ra05383h
000063282 0248_ $$2sideral$$a101184
000063282 037__ $$aART-2015-101184
000063282 041__ $$aeng
000063282 100__ $$0(orcid)0000-0002-0769-7168$$aAlegre-Requena, Juan V.
000063282 245__ $$aOne-pot synthesis of unsymmetrical squaramides
000063282 260__ $$c2015
000063282 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063282 5203_ $$aThe results concerning the first one-pot synthesis of unsymmetrical squaramides are reported. This straightforward procedure allows appealing and commonly used squaramide derivatives to be obtained with very good results. The methodology developed in this work saves energy, eliminates the purification steps for intermediate products, reduces costs and leads to better yields compared to those obtained through the traditional “stop-and-go” approach. Moreover, we have proved the efficiency of our process with the synthesis of three biologically active structures, improving the results of the previously reported stepwise syntheses. Interestingly, this simple and cheap method could attract the interest of pharmaceutical and chemical companies aiming to produce these active compounds on a large scale.
000063282 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000063282 590__ $$a3.289$$b2015
000063282 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b48 / 162 = 0.296$$c2015$$dQ2$$eT1
000063282 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000063282 700__ $$0(orcid)0000-0001-6832-8983$$aMarqués-López, Eugenia$$uUniversidad de Zaragoza
000063282 700__ $$0(orcid)0000-0002-5244-9569$$aHerrera, Raquel P.$$uUniversidad de Zaragoza
000063282 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDepartamento de Química Orgánica$$cQuímica Orgánica
000063282 773__ $$g5 (2015), [15 pp.]$$pRSC ADVANCES$$tRSC ADVANCES$$x2046-2069
000063282 8564_ $$s550397$$uhttp://zaguan.unizar.es/record/63282/files/texto_completo.pdf$$yPostprint
000063282 8564_ $$s91047$$uhttp://zaguan.unizar.es/record/63282/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000063282 909CO $$ooai:zaguan.unizar.es:63282$$particulos$$pdriver
000063282 951__ $$a2017-11-28-12:45:23
000063282 980__ $$aARTICLE