Multinuclear nanoliter one-dimensional and two-dimensional NMR spectroscopy with a single non-resonant microcoil
Resumen: Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical technique, but its low sensitivity and highly sophisticated, costly, equipment severely constrain more widespread applications. Here we show that a non-resonant planar transceiver microcoil integrated in a microfluidic chip (detection volume 25¿nl) can detect different nuclides in the full broad-band range of Larmor frequencies (at 9.4¿T from 61 to 400¿MHz). Routine one-dimensional (1D) and two-dimensional (2D), homo- and heteronuclear experiments can be carried out using the broad-band coil set-up. Noteworthy, heteronuclear 2D experiments can be performed in a straightforward manner on virtually any combination of nuclides (from classical 1H–13C to more exotic combinations like 19F–31P) both in coupled and decoupled mode. Importantly, the concept of a non-resonant system provides magnetic field-independent NMR probes; moreover, the small-volume alleviates problems related to field inhomogeneity, making the broad-band coil an attractive option for, for example, portable and table-top NMR systems.
Idioma: Inglés
DOI: 10.1038/ncomms4025
Año: 2014
Publicado en: NATURE COMMUNICATIONS 5, 3025 (2014), 1-8
ISSN: 2041-1723

Factor impacto: 11.47 (2014)
Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 3 / 57 = 0.053 (2014) - Q1 - T1
Tipo y forma: Article (Published version)
Área (Departamento): Química Orgánica (Departamento de Química Orgánica)

Creative Commons You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

Exportado de SIDERAL (2017-11-28-12:45:14)

Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Química Orgánica

 Record created 2017-11-28, last modified 2017-11-29

Versión publicada:
Rate this document:

Rate this document:
(Not yet reviewed)