000063278 001__ 63278
000063278 005__ 20171129112116.0
000063278 0247_ $$2doi$$a10.1038/ncomms4025
000063278 0248_ $$2sideral$$a85754
000063278 037__ $$aART-2014-85754
000063278 041__ $$aeng
000063278 100__ $$0(orcid)0000-0001-5559-8757$$aFratila, Raluca M.$$uUniversidad de Zaragoza
000063278 245__ $$aMultinuclear nanoliter one-dimensional and two-dimensional NMR spectroscopy with a single non-resonant microcoil
000063278 260__ $$c2014
000063278 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063278 5203_ $$aNuclear magnetic resonance (NMR) spectroscopy is a powerful analytical technique, but its low sensitivity and highly sophisticated, costly, equipment severely constrain more widespread applications. Here we show that a non-resonant planar transceiver microcoil integrated in a microfluidic chip (detection volume 25¿nl) can detect different nuclides in the full broad-band range of Larmor frequencies (at 9.4¿T from 61 to 400¿MHz). Routine one-dimensional (1D) and two-dimensional (2D), homo- and heteronuclear experiments can be carried out using the broad-band coil set-up. Noteworthy, heteronuclear 2D experiments can be performed in a straightforward manner on virtually any combination of nuclides (from classical 1H–13C to more exotic combinations like 19F–31P) both in coupled and decoupled mode. Importantly, the concept of a non-resonant system provides magnetic field-independent NMR probes; moreover, the small-volume alleviates problems related to field inhomogeneity, making the broad-band coil an attractive option for, for example, portable and table-top NMR systems.
000063278 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063278 590__ $$a11.47$$b2014
000063278 591__ $$aMULTIDISCIPLINARY SCIENCES$$b3 / 57 = 0.053$$c2014$$dQ1$$eT1
000063278 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000063278 700__ $$aGomez, M. Victoria
000063278 700__ $$aSykora, Stanislav
000063278 700__ $$aVelders, Aldrik H.
000063278 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDepartamento de Química Orgánica$$cQuímica Orgánica
000063278 773__ $$g5, 3025 (2014), 1-8$$pNATURE COMMUNICATIONS$$tNATURE COMMUNICATIONS$$x2041-1723
000063278 8564_ $$s466365$$uhttp://zaguan.unizar.es/record/63278/files/texto_completo.pdf$$yVersión publicada
000063278 8564_ $$s64749$$uhttp://zaguan.unizar.es/record/63278/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063278 909CO $$ooai:zaguan.unizar.es:63278$$particulos$$pdriver
000063278 951__ $$a2017-11-28-12:45:14
000063278 980__ $$aARTICLE