000063234 001__ 63234
000063234 005__ 20171117104915.0
000063234 0247_ $$2doi$$a10.1097/MD.0000000000000176
000063234 0248_ $$2sideral$$a100184
000063234 037__ $$aART-2014-100184
000063234 041__ $$aeng
000063234 100__ $$aHuerva, V.
000063234 245__ $$aInfliximab for peripheral ulcerative keratitis treatment
000063234 260__ $$c2014
000063234 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063234 5203_ $$aBiologic agents such as anti-TNFa have been employed in treatment paradigms for ocular inflammation. Peripheral corneal ulceration (PUK) is a devastating disorder consisting of a crescent-shaped area of destructive inflammation at the margin of the corneal stroma. It is associated with an epithelial defect, the presence of stromal inflammatory cells, and progressive stromal degradation and thinning, leading to ocular perforation and devastating visual loss. Macroulcerative PUK is usually a local manifestation of a systemic vasculitis. In many cases, the disease may be resistant to high doses of systemic corticosteroids and immunosuppressants. Chimeric anti-TNFa has been employed when all other treatments have failed. Isolated cases and short series of cases have been reported. This paper summarizes the available reports on the use, efficacy, and safety of infliximab in the treatment of PUK.
000063234 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063234 590__ $$a5.723$$b2014
000063234 591__ $$aMEDICINE, GENERAL & INTERNAL$$b15 / 154 = 0.097$$c2014$$dQ1$$eT1
000063234 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000063234 700__ $$0(orcid)0000-0001-9876-5850$$aAscaso, F. J.$$uUniversidad de Zaragoza
000063234 700__ $$aGrzybowski, A.
000063234 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDepartamento de Cirugía, Ginecología y Obstetricia$$cOftalmología
000063234 773__ $$g93, 26 (2014), e176 [4 pp]$$pMedicine (Baltim.)$$tMedicine (Baltimore)$$x0025-7974
000063234 8564_ $$s111065$$uhttp://zaguan.unizar.es/record/63234/files/texto_completo.pdf$$yVersión publicada
000063234 8564_ $$s8405$$uhttp://zaguan.unizar.es/record/63234/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063234 909CO $$ooai:zaguan.unizar.es:63234$$particulos$$pdriver
000063234 951__ $$a2017-11-16-13:55:02
000063234 980__ $$aARTICLE