000063206 001__ 63206
000063206 005__ 20190709135517.0
000063206 0247_ $$2doi$$a10.1371/journal.pone.0185889
000063206 0248_ $$2sideral$$a101948
000063206 037__ $$aART-2017-101948
000063206 041__ $$aeng
000063206 100__ $$aPerrotti, P.P.
000063206 245__ $$aGenetic variation associated with cardiovascular risk in autoimmune diseases
000063206 260__ $$c2017
000063206 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063206 5203_ $$aAutoimmune diseases have a higher prevalence of cardiovascular events compared to the general population. The objective of this study was to investigate the genetic basis of cardiovascular disease (CVD) risk in autoimmunity. We analyzed genome-wide genotyping data from 6, 485 patients from six autoimmune diseases that are associated with a high socioeconomic impact. First, for each disease, we tested the association of established CVD risk loci. Second, we analyzed the association of autoimmune disease susceptibility loci with CVD. Finally, to identify genetic patterns associated with CVD risk, we applied the cross-phenotype meta-analysis approach (CPMA) on the genome-wide data. A total of 17 established CVD risk loci were significantly associated with CVD in the autoimmune patient cohorts. From these, four loci were found to have significantly different genetic effects across autoimmune diseases. Six autoimmune susceptibility loci were also found to be associated with CVD risk. Genome-wide CPMA analysis identified 10 genetic clusters strongly associated with CVD risk across all autoimmune diseases. Two of these clusters are highly enriched in pathways previously associated with autoimmune disease etiology (TNFa and IFN¿ cytokine pathways). The results of this study support the presence of specific genetic variation associated with the increase of CVD risk observed in autoimmunity.
000063206 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/IPT-010000-2010-36$$9info:eu-repo/grantAgreement/ES/MINECO/PSE-010000-2006-6
000063206 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063206 590__ $$a2.766$$b2017
000063206 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 64 = 0.234$$c2017$$dQ1$$eT1
000063206 592__ $$a1.164$$b2017
000063206 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2017$$dQ1
000063206 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1
000063206 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2017$$dQ1
000063206 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000063206 700__ $$aAterido, A.
000063206 700__ $$aFernández-Nebro, A.
000063206 700__ $$aCañete, J.D.
000063206 700__ $$aFerrándiz, C.
000063206 700__ $$aTornero, J.
000063206 700__ $$aGisbert, J.P.
000063206 700__ $$aDomènech, E.
000063206 700__ $$aFernández-Gutiérrez, B.
000063206 700__ $$0(orcid)0000-0003-0076-3529$$aGomollón, Fernando$$uUniversidad de Zaragoza
000063206 700__ $$aGarcía-Planella, E.
000063206 700__ $$aFernández, E.
000063206 700__ $$aSanmartí, R.
000063206 700__ $$aGratacós, J.
000063206 700__ $$aMartínez-Taboada, V.M.
000063206 700__ $$aRodríguez-Rodríguez, L.
000063206 700__ $$aPalau, N.
000063206 700__ $$aTortosa, R.
000063206 700__ $$aCorbeto, M.L.
000063206 700__ $$aLasanta, M.L.
000063206 700__ $$aMarsal, S.
000063206 700__ $$aJulià, A.
000063206 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000063206 773__ $$g12, 10 (2017), e0185889$$pPLoS One$$tPloS one$$x1932-6203
000063206 8564_ $$s1980914$$uhttps://zaguan.unizar.es/record/63206/files/texto_completo.pdf$$yVersión publicada
000063206 8564_ $$s108199$$uhttps://zaguan.unizar.es/record/63206/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063206 909CO $$ooai:zaguan.unizar.es:63206$$particulos$$pdriver
000063206 951__ $$a2019-07-09-11:56:00
000063206 980__ $$aARTICLE