000063015 001__ 63015
000063015 005__ 20240104111805.0
000063015 0247_ $$2doi$$a10.1371/journal.pone.0184626
000063015 0248_ $$2sideral$$a101634
000063015 037__ $$aART-2017-101634
000063015 041__ $$aeng
000063015 100__ $$0(orcid)0000-0003-3069-9994$$aGasco, Samanta
000063015 245__ $$aInflammatory and non-inflammatory monocytes as novel prognostic biomarkers of survival in SOD1G93A mouse model of Amyotrophic Lateral Sclerosis
000063015 260__ $$c2017
000063015 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063015 5203_ $$aAmyotrophic Lateral Sclerosis (ALS) has lately become a suitable scenario to study the interplay between the hematopoietic system and disease progression. Recent studies in C9orf72 null mice have demonstrated that C9orf72 is necessary for the normal function of myeloid cells. In this study, we aimed to analyze in depth the connection between the hematopoietic system and secondary lymphoid (spleen) and non-lymphoid (liver and skeletal muscle) organs and tissues along the disease progression in the transgenic SOD1G93A mice. Our findings suggested that the inflammatory response due to the neurodegeneration in this animal model affected all three organs and tissues, especially the liver and the skeletal muscle. However, the liver was able to compensate this inflammatory response by means of the action of non-inflammatory monocytes, while in the skeletal muscle inflammatory monocytes prompted a further inflammation process until the terminal state of the animals. Interestingly, in blood, a positive correlation was found between non-inflammatory monocytes and survival of the transgenic SOD1G93A mice, while the contrary (a negative correlation) was found in the case of inflammatory monocytes, supporting their potential role as biomarkers of disease progression and survival in this animal model. These findings could prompt future translational studies in ALS patients, promoting the identification of new reliable biomarkers of disease progression.
000063015 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI14-00947
000063015 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063015 590__ $$a2.766$$b2017
000063015 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 64 = 0.234$$c2017$$dQ1$$eT1
000063015 592__ $$a1.164$$b2017
000063015 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2017$$dQ1
000063015 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1
000063015 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2017$$dQ1
000063015 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000063015 700__ $$0(orcid)0000-0001-5740-0185$$aZaragoza, Pilar$$uUniversidad de Zaragoza
000063015 700__ $$0(orcid)0000-0001-7646-386X$$aGarcía-Redondo, Alberto
000063015 700__ $$0(orcid)0000-0001-5193-7782$$aCalvo, Ana C.$$uUniversidad de Zaragoza
000063015 700__ $$0(orcid)0000-0001-5687-6704$$aOsta, Rosario$$uUniversidad de Zaragoza
000063015 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000063015 773__ $$g12, 9 (2017), e0184626$$pPLoS One$$tPLoS ONE$$x1932-6203
000063015 8564_ $$s5813098$$uhttps://zaguan.unizar.es/record/63015/files/texto_completo.pdf$$yVersión publicada
000063015 8564_ $$s102402$$uhttps://zaguan.unizar.es/record/63015/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063015 909CO $$ooai:zaguan.unizar.es:63015$$particulos$$pdriver
000063015 951__ $$a2024-01-04-11:00:14
000063015 980__ $$aARTICLE