000062118 001__ 62118
000062118 005__ 20200221144345.0
000062118 0248_ $$2sideral$$a101400
000062118 037__ $$aART-2016-101400
000062118 041__ $$aeng
000062118 100__ $$aRodríguez-Valle, A.
000062118 245__ $$aEffect of two days treatment with orlistat on plasma leptin in obese patients without weight loss
000062118 260__ $$c2016
000062118 5060_ $$aAccess copy available to the general public$$fUnrestricted
000062118 5203_ $$aObjective: Little is known about the impact of orlistat on the leptin system. We studied the plasma leptin and satiety sensation response for two days of orlistat treatment without hypocaloric diet and weight loss. Material and methods: Twenty obese female subjects were recruited from our medical outpatient clinics. All of these subjects had previously received advice on dietary restriction and lifestyle modification, but remained obese with a stable body weight for at least six months before recruitment for the study. Results: Subjects were given 120 mg orlistat 3 times daily and were asked to maintain their usual diet. At baseline and two days after the treatment with orlistat, physical examination, hunger and blood analysis were repeated. There were no significant differences observed regarding energy dietary intake, body weight and waist-hip ratio, or in plasma glucose, insulin c-peptide concentrations. Only plasma leptin and triglycerides concentrations decreased (p: 0.0001 and 0.01 respectively). Decrease in plasma leptin concentration was positively correlated with changes observed in plasma triglycerides concentration (p: 0.01, r2: 0.45). Pre-dinner hunger increased and was negatively correlated with decrease in leptin (p: 0.0001, r2: 0.74) and triglycerides (p: 0.02, r2: 0.59). Conclusion: These data suggest that the partial fat malabsorption induced by the treatment with orlistat quickly reduces plasma triglycerides and leptin. This decrease is associated with increased appetite before intake following the main meal of the day.
000062118 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000062118 590__ $$a0.747$$b2016
000062118 591__ $$aNUTRITION & DIETETICS$$b68 / 81 = 0.84$$c2016$$dQ4$$eT3
000062118 592__ $$a0.4$$b2016
000062118 593__ $$aNutrition and Dietetics$$c2016$$dQ3
000062118 593__ $$aMedicine (miscellaneous)$$c2016$$dQ3
000062118 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000062118 700__ $$0(orcid)0000-0002-0108-1004$$aNavarro-Ferrando, M.Á.$$uUniversidad de Zaragoza
000062118 700__ $$aBoj-Carceller, D.$$uUniversidad de Zaragoza
000062118 700__ $$0(orcid)0000-0002-6012-7412$$aEscanero-Marcén, J.F.$$uUniversidad de Zaragoza
000062118 700__ $$0(orcid)0000-0002-7758-3588$$aSanz-Paris, A.$$uUniversidad de Zaragoza
000062118 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000062118 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000062118 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000062118 773__ $$g33, 2 (2016), 292-297$$pNutr. hosp.$$tNUTRICION HOSPITALARIA$$x0212-1611
000062118 85641 $$uhttp://scielo.isciii.es/pdf/nh/v33n2/17_original15.pdf$$zTexto completo de la revista
000062118 8564_ $$s682354$$uhttps://zaguan.unizar.es/record/62118/files/texto_completo.pdf$$yVersión publicada
000062118 8564_ $$s80139$$uhttps://zaguan.unizar.es/record/62118/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000062118 909CO $$ooai:zaguan.unizar.es:62118$$particulos$$pdriver
000062118 951__ $$a2020-02-21-13:52:16
000062118 980__ $$aARTICLE