000062007 001__ 62007
000062007 005__ 20190709135457.0
000062007 0247_ $$2doi$$a10.1002/cphc.201700180
000062007 0248_ $$2sideral$$a99794
000062007 037__ $$aART-2017-99794
000062007 041__ $$aeng
000062007 100__ $$aMayans, E.
000062007 245__ $$aEffect of Solvent Choice on the Self-Assembly Properties of a Diphenylalanine Amphiphile Stabilized by an Ion Pair
000062007 260__ $$c2017
000062007 5060_ $$aAccess copy available to the general public$$fUnrestricted
000062007 5203_ $$aA diphenylalanine (FF) amphiphile blocked at the C terminus with a benzyl ester (OBzl) and stabilized at the N terminus with a trifluoroacetate (TFA) anion was synthetized and characterized. Aggregation of peptide molecules was studied by considering a peptide solution in an organic solvent and adding pure water, a KCl solution, or another organic solvent as co-solvent. The choice of the organic solvent and co-solvent and the solvent/co-solvent ratio allowed the mixture to be tuned by modulating the polarity, the ionic strength, and the peptide concentration. Differences in the properties of the media used to dissolve the peptides resulted in the formation of different self-assembled microstructures (e.g. fibers, branched-like structures, plates, and spherulites). Furthermore, crystals of TFAFF-OBzl were obtained from the aqueous peptide solutions for X-ray diffraction analysis. The results revealed a hydrophilic core constituted by carboxylate (from TFA), ester, and amide groups, and the core was found to be surrounded by a hydrophobic crown with ten aromatic rings. This segregated organization explains the assemblies observed in the different solvent mixtures as a function of the environmental polarity, ionic strength, and peptide concentration.
000062007 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/MAT2015-69547-R$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/MAT2015-69367-R$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2013-40855-R$$9info:eu-repo/grantAgreement/ES/DGA/E40
000062007 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000062007 590__ $$a2.947$$b2017
000062007 591__ $$aPHYSICS, ATOMIC, MOLECULAR & CHEMICAL$$b11 / 36 = 0.306$$c2017$$dQ2$$eT1
000062007 591__ $$aCHEMISTRY, PHYSICAL$$b62 / 146 = 0.425$$c2017$$dQ2$$eT2
000062007 592__ $$a1.28$$b2017
000062007 593__ $$aPhysical and Theoretical Chemistry$$c2017$$dQ1
000062007 593__ $$aAtomic and Molecular Physics, and Optics$$c2017$$dQ1
000062007 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000062007 700__ $$aBallano, G.
000062007 700__ $$aSendros, J.
000062007 700__ $$aFont-Bardia, M.
000062007 700__ $$aCampos, J.L.
000062007 700__ $$aPuiggalí, J.
000062007 700__ $$0(orcid)0000-0003-3222-0828$$aCativiela, C.$$uUniversidad de Zaragoza
000062007 700__ $$aAlemán, C.
000062007 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000062007 773__ $$g18 (2017), 1888-1896$$pChemphyschem$$tCHEMPHYSCHEM$$x1439-4235
000062007 8564_ $$s2027631$$uhttps://zaguan.unizar.es/record/62007/files/texto_completo.pdf$$yVersión publicada
000062007 8564_ $$s111375$$uhttps://zaguan.unizar.es/record/62007/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000062007 909CO $$ooai:zaguan.unizar.es:62007$$particulos$$pdriver
000062007 951__ $$a2019-07-09-11:44:21
000062007 980__ $$aARTICLE