000061789 001__ 61789
000061789 005__ 20201105083206.0
000061789 0247_ $$2doi$$a10.1371/journal.pone.0177163
000061789 0248_ $$2sideral$$a99744
000061789 037__ $$aART-2017-99744
000061789 041__ $$aeng
000061789 100__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E.$$uUniversidad de Zaragoza
000061789 245__ $$aComparison of peripapillary choroidal thickness between healthy subjects and patients with Parkinson's disease
000061789 260__ $$c2017
000061789 5060_ $$aAccess copy available to the general public$$fUnrestricted
000061789 5203_ $$aPurpose: To study peripapillary choroidal thickness (PPCT) in healthy subjects using swept-source optical coherence tomography (SS-OCT), and to evaluate PPCT differences between Parkinson''s disease (PD) patients, and age- and sex-matched healthy controls. Design: Case-control study Methods: 80 healthy subjects and 40 PD patients were consecutively recruited in this single institution study. The healthy subjects were divided into two populations: a teaching population (n = 40, used to establish choroidal zones) and a validating population (n = 40, used to compare measurements with PD patients). An optic disc 6.0x6.0 mm three-dimensional scan was obtained using Deep Range Imaging (DRI) OCT Triton. A 26x26 cube-grid centered on the optic disc was generated to automatically measure choroidal thickness. Five concentric choroidal zones were established and used to compare PPCT between healthy and PD patients. Results: PPCT was significantly thicker in PD patients compared with controls in all four concentric zones evaluated (p=0.0001). PPCT followed a similar pattern in controls and PD; it was thicker in the temporosuperior region, followed by the superior, temporal, nasal, and inferior regions. Conclusion: PD patients presented with an increased PPCT in all zones surrounding the optic disc compared with healthy subjects. The peripapillary choroidal tissue showed a concentric pattern, with the thickness increasing with increasing distance from the optic nerve. SS-OCT could be useful for evaluating choroidal thinning in clinical practice.
000061789 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000061789 590__ $$a2.766$$b2017
000061789 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 64 = 0.234$$c2017$$dQ1$$eT1
000061789 592__ $$a1.164$$b2017
000061789 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2017$$dQ1
000061789 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1
000061789 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2017$$dQ1
000061789 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000061789 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, L.E.$$uUniversidad de Zaragoza
000061789 700__ $$0(orcid)0000-0001-5320-7839$$aBambo, M.P.$$uUniversidad de Zaragoza
000061789 700__ $$aAlarcia, R.
000061789 700__ $$0(orcid)0000-0002-1402-3129$$aPolo, V.$$uUniversidad de Zaragoza
000061789 700__ $$0(orcid)0000-0002-6745-7668$$aLarrosa, J.M.$$uUniversidad de Zaragoza
000061789 700__ $$aVilades, E.
000061789 700__ $$aCameo, B.
000061789 700__ $$aOrduna, E.
000061789 700__ $$aRamirez, T.
000061789 700__ $$aSatue, M.
000061789 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000061789 773__ $$g12, 5 (2017), e0177163 [13pp]$$pPLoS One$$tPloS one$$x1932-6203
000061789 8564_ $$s14290889$$uhttps://zaguan.unizar.es/record/61789/files/texto_completo.pdf$$yVersión publicada
000061789 8564_ $$s87399$$uhttps://zaguan.unizar.es/record/61789/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000061789 909CO $$ooai:zaguan.unizar.es:61789$$particulos$$pdriver
000061789 951__ $$a2020-11-05-08:18:38
000061789 980__ $$aARTICLE