000061714 001__ 61714
000061714 005__ 20190709135448.0
000061714 0247_ $$2doi$$a10.1039/c6ra28316k
000061714 0248_ $$2sideral$$a99209
000061714 037__ $$aART-2017-99209
000061714 041__ $$aeng
000061714 100__ $$0(orcid)0000-0002-2202-3460$$aMerino, P.$$uUniversidad de Zaragoza
000061714 245__ $$aChemical approaches to inhibitors of isoprenoid biosynthesis: targeting farnesyl and geranylgeranyl pyrophosphate synthases
000061714 260__ $$c2017
000061714 5060_ $$aAccess copy available to the general public$$fUnrestricted
000061714 5203_ $$aPost-translational lipid modifications farnesylation and geranylgeranylation of proteins (protein prenylation) have been identified to mediate critical events in cancer, cardiovascular disorders, malaria and bone disorders like osteoporosis. To date eight compounds are commercialized for the treatment of bone disorders, and there are considerable efforts to develop selective small molecules that inhibit protein prenylation. This review summarizes the approaches currently employed to synthesize new inhibitors of isoprenoid biosynthesis. Bisphosphonates are mainly prepared through reaction of carboxylic acids with phosphorus reagents, Michael addition to tetraethylvinylidenebisphosphonate and alkylation of tetralkylmethyl bisphosphonate. Approaches to non-bisphosphonate derivatives include a variety of methodologies depending on the structure of the target compound.
000061714 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E10$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2016-76155-R
000061714 540__ $$9info:eu-repo/semantics/openAccess$$aby-sa$$uhttp://creativecommons.org/licenses/by-sa/3.0/es/
000061714 590__ $$a2.936$$b2017
000061714 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b71 / 171 = 0.415$$c2017$$dQ2$$eT2
000061714 592__ $$a0.863$$b2017
000061714 593__ $$aChemistry (miscellaneous)$$c2017$$dQ1
000061714 593__ $$aChemical Engineering (miscellaneous)$$c2017$$dQ1
000061714 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000061714 700__ $$aMaiuolo, L.
000061714 700__ $$0(orcid)0000-0001-8355-2289$$aDelso, I.$$uUniversidad de Zaragoza
000061714 700__ $$aAlgieri, V.
000061714 700__ $$aDe Nino, A.
000061714 700__ $$0(orcid)0000-0003-3433-6701$$aTejero, T.$$uUniversidad de Zaragoza
000061714 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000061714 773__ $$g7, 18 (2017), 10947-10967$$pRSC ADVANCES$$tRSC Advances$$x2046-2069
000061714 8564_ $$s2403826$$uhttps://zaguan.unizar.es/record/61714/files/texto_completo.pdf$$yVersión publicada
000061714 8564_ $$s106455$$uhttps://zaguan.unizar.es/record/61714/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000061714 909CO $$ooai:zaguan.unizar.es:61714$$particulos$$pdriver
000061714 951__ $$a2019-07-09-11:39:25
000061714 980__ $$aARTICLE