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000061570 005__ 20181123104108.0
000061570 0248_ $$2sideral$$a98454
000061570 037__ $$aART-2016-98454
000061570 041__ $$aeng
000061570 100__ $$aCaiani, E. G.
000061570 245__ $$aAortic flow and morphology adaptation to deconditioning after 21-days of head-down bed-rest assessed by phase contrast MRI
000061570 260__ $$c2016
000061570 5060_ $$aAccess copy available to the general public$$fUnrestricted
000061570 5203_ $$aOur aim was to assess the effects of 21-days head-down (-6 degrees) bed-rest (BR) and effectiveness of sledge jump countermeasure (CM), on aortic flow and morphology by Phase Contrast (PC) MRI. Male subjects were enrolled at :envihub (DLR, Germany) in control (CTRL, N=12) or countermeasure (CM, N=12) groups. PC-MRI images were obtained before and after 21-days of BR, and analyzed with custom software. Semi-automated region growing and thresholding were applied to segment the aortic lumen, and to compute parameters from velocity images: area lumen (AL), flow velocity, stroke volume (SV), flow rate (Qpeak), time-to-peak flow, systolic duration and heart beat duration (RR). After 21 days, in CTRL significant decreases in SV (14%), Qpeak (5%) and AL (4%) were observed compared to baseline values. Conversely, for CM no changes were observed in these parameters, but only in RR (-8%). Cardiac adaptation to deconditioning due to immobilization resulted in a reduction of SV and Qpeak that might have induced a remodeling process in the ascending aorta, by shrinking of its lumen. The applied CM seemed to counteract at least partially these effects.
000061570 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T96$$9info:eu-repo/grantAgreement/ES/MINECO/TEC2013-42140-R
000061570 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000061570 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000061570 700__ $$aRiso, G.
000061570 700__ $$aLandreani, F.
000061570 700__ $$0(orcid)0000-0003-0226-4950$$aMartin-Yebra, A.
000061570 700__ $$aPirola, S.
000061570 700__ $$aPiatti, F.
000061570 700__ $$aSturla, F.
000061570 700__ $$aVaida, P.
000061570 700__ $$aMigeotte, P. -F
000061570 773__ $$g43 (2016), 73-76$$pComput. cardiol.$$tComputing in Cardiology$$x2325-8861
000061570 85641 $$uhttp://ieeexplore.ieee.org/document/7868682/$$zTexto completo de la revista
000061570 8564_ $$s261476$$uhttps://zaguan.unizar.es/record/61570/files/texto_completo.pdf$$yVersión publicada
000061570 8564_ $$s107368$$uhttps://zaguan.unizar.es/record/61570/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000061570 909CO $$ooai:zaguan.unizar.es:61570$$particulos$$pdriver
000061570 951__ $$a2018-11-23-10:33:23
000061570 980__ $$aARTICLE