000061545 001__ 61545
000061545 005__ 20210902121558.0
000061545 0247_ $$2doi$$a10.1039/c6ra01714b
000061545 0248_ $$2sideral$$a94008
000061545 037__ $$aART-2016-94008
000061545 041__ $$aeng
000061545 100__ $$0(orcid)0000-0002-0922-5615$$aOriol Langa, Luis Teodoro$$uUniversidad de Zaragoza
000061545 245__ $$aPolymeric micelles from block copolymers containing 2,6-diacylaminopyridine units for encapsulation of hydrophobic drugs
000061545 260__ $$c2016
000061545 5060_ $$aAccess copy available to the general public$$fUnrestricted
000061545 5203_ $$aThe paper describes the synthesis and characterization of novel amphiphilic block copolymers composed of a hydrophilic (polyethylene glycol) block and a hydrophobic polymetacrylate block with pendant 2,6-acylaminopyridine units. As demonstrated by TEM, these polymers are capable of forming stable spherical micelles in water with diameters of 18-25 nm, depending on the average molar mass, determined by dynamic light scattering. The polymeric micelles are sensitive to pH and can encapsulate hydrophobic molecules such as Nile Red. The cytotoxicity of the block copolymers has been tested in HeLa and Lunet cell lines and proved to be adequate. The polymeric micelles have been used to load camptothecin (CPT), an effective antiviral against hepatitis C virus (HCV), by simple physical diffusion. The antiviral activity against HVC of these CPT-loaded polymeric micelles has been tested on Huh 5-2 Lunet cells, demonstrating the potential of these polymers as nanocarriers for drug delivery applications.
000061545 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/BFU2013-47064-P$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2014-55205-P
000061545 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000061545 590__ $$a3.108$$b2016
000061545 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b59 / 166 = 0.355$$c2016$$dQ2$$eT2
000061545 592__ $$a0.889$$b2016
000061545 593__ $$aChemistry (miscellaneous)$$c2016$$dQ1
000061545 593__ $$aChemical Engineering (miscellaneous)$$c2016$$dQ1
000061545 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000061545 700__ $$0(orcid)0000-0002-8932-9085$$aConcellón, A.$$uUniversidad de Zaragoza
000061545 700__ $$aClavería-Gimeno, R.
000061545 700__ $$0(orcid)0000-0001-5702-4538$$aVelázquez-Campoy, A.$$uUniversidad de Zaragoza
000061545 700__ $$0(orcid)0000-0001-5664-1729$$aAbian, O.$$uUniversidad de Zaragoza
000061545 700__ $$0(orcid)0000-0001-5556-2172$$aPiñol, M.$$uUniversidad de Zaragoza
000061545 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000061545 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000061545 773__ $$g6, 29 (2016), 24066 - 24075$$pRSC ADVANCES$$tRSC Advances$$x2046-2069
000061545 8564_ $$s1190183$$uhttps://zaguan.unizar.es/record/61545/files/texto_completo.pdf$$yVersión publicada
000061545 8564_ $$s120070$$uhttps://zaguan.unizar.es/record/61545/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000061545 909CO $$ooai:zaguan.unizar.es:61545$$particulos$$pdriver
000061545 951__ $$a2021-09-02-08:33:31
000061545 980__ $$aARTICLE