000061427 001__ 61427
000061427 005__ 20170612112601.0
000061427 0247_ $$2doi$$a10.1002/chem.201502691
000061427 0248_ $$2sideral$$a93257
000061427 037__ $$aART-2015-93257
000061427 041__ $$aeng
000061427 100__ $$aSiebel, S.
000061427 245__ $$aAnalogues of Cis- and Transplatin with a Rich Solution Chemistry: Cis-[PtCl2(NH3)(1-MeC-N3)] and trans-[PtI2(NH3)(1-MeC-N3)]
000061427 260__ $$c2015
000061427 5060_ $$aAccess copy available to the general public$$fUnrestricted
000061427 5203_ $$aMono(nucleobase) complexes of the general composition cis-PtCl2(NH3)L] with L=1-methylcytosine, 1-MeC (1 a) and L=1-ethyl-5-methylcytosine, as well as trans-PtX2(NH3)(1-MeC)] with X=I (5 a) and X=Br (5 b) have been isolated and were characterized by X-ray crystallography. The Pt coordination occurs through the N3 atom of the cytosine in all cases. The diaqua complexes of compounds 1 a and 5 a, cis-Pt(H2O)2(NH3)(1-MeC)]2+ and trans-Pt(H2O)2(NH3)(1-MeC)]2+, display a rich chemistry in aqueous solution, which is dominated by extensive condensation reactions leading to µ-OH- and µ-(1-MeC--N3, N4)-bridged species and ready oxidation of Pt to mixed-valence state complexes as well as diplatinum(III) compounds, one of which was characterized by X-ray crystallography: h, t-{Pt(NH3)2(OH)(1-MeC--N3, N4)}2](NO3)2.2 NH4](NO3).2 H2O. A combination of 1H NMR spectroscopy and ESI mass spectrometry was applied to identify some of the various species present in solution and the gas phase, respectively. As it turned out, mass spectrometry did not permit an unambiguous assignment of the structures of +1 cations due to the possibilities of realizing multiple bridging patterns in isomeric species, the occurrence of different tautomers, and uncertainties regarding the Pt oxidation states. Additionally, compound 1 a was found to have selective and moderate antiproliferative activity for a human cervix cancer line (SISO) compared to six other human cancer cell lines.
000061427 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000061427 590__ $$a5.771$$b2015
000061427 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b24 / 162 = 0.148$$c2015$$dQ1$$eT1
000061427 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000061427 700__ $$aDammann, C.
000061427 700__ $$0(orcid)0000-0002-8220-6031$$aSanz Miguel, P. J.$$uUniversidad de Zaragoza
000061427 700__ $$aDrewello, T.
000061427 700__ $$aKampf, G.
000061427 700__ $$aTeubner, N.
000061427 700__ $$aBednarski, P. J.
000061427 700__ $$aFreisinger, E.
000061427 700__ $$aLippert, B.
000061427 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDepartamento de Química Inorgánica$$cQuímica Inorgánica
000061427 773__ $$g21, 49 (2015), 17827-17843$$pChemistry (Weinh.)$$tCHEMISTRY-A EUROPEAN JOURNAL$$x0947-6539
000061427 8564_ $$s2362242$$uhttp://zaguan.unizar.es/record/61427/files/texto_completo.pdf$$yPostprint
000061427 8564_ $$s84419$$uhttp://zaguan.unizar.es/record/61427/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000061427 909CO $$ooai:zaguan.unizar.es:61427$$particulos$$pdriver
000061427 951__ $$a2017-06-12-09:13:20
000061427 980__ $$aARTICLE