000061290 001__ 61290
000061290 005__ 20200221144244.0
000061290 0247_ $$2doi$$a10.1093/schbul/sbv078
000061290 0248_ $$2sideral$$a93436
000061290 037__ $$aART-2016-93436
000061290 041__ $$aeng
000061290 100__ $$aMartinez-Cengotitabengoa, M.
000061290 245__ $$aBDNF and NGF Signalling in Early Phases of Psychosis: Relationship with Inflammation and Response to Antipsychotics after 1 Year
000061290 260__ $$c2016
000061290 5060_ $$aAccess copy available to the general public$$fUnrestricted
000061290 5203_ $$aPrevious studies have indicated systemic deregulation of the proinflammatory or anti-inflammatory balance in individuals with first-episode psychosis (FEP) that persists 12 months later. To identify potential risk/protective factors and associations with symptom severity, we assessed possible changes in plasma levels of neurotrophins (brain-derived neurotrophic factor BDNF] and nerve growth factor NGF]) and their receptors in peripheral blood mononuclear cells (PBMCs). Expression of the 2 forms of BDNF receptors (active TrkB-FL and inactiveTrkB-T1) in PBMCs of FEP patients changed over time, TrkB-FL expression increasing by 1 year after diagnosis, while TrkB-T1 expression decreased. The TrkB-FL/TrkB-T1 ratio (hereafter FL/T1 ratio) increased during follow-up in the nonaffective psychosis group only, suggesting different underlying pathophysiological mechanisms in subgroups of FEP patients. Further, the expression of the main NGF receptor, TrkA, generally increased in patients at follow-up. After adjusting for potential confounders, baseline levels of inducible isoforms of nitric oxide synthase, cyclooxygenase, and nuclear transcription factor were significantly associated with the FL/T1 ratio, suggesting that more inflammation is associated with higher values of this ratio. Interestingly, the FL/T1 ratio might have a role as a predictor of functioning, a regression model of functioning at 1 year suggesting that the effect of the FL/T1 ratio at baseline on functioning at 1 year depended on whether patients were treated with antipsychotics. These findings may have translational relevance; specifically, it might be useful to assess the expression of TrkB receptor isoforms before initiating antipsychotic treatment in FEPs.
000061290 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/CIBERSAM$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/PI12-02077$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/PI11-02708$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/PI11-01977$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/PI10-01746
000061290 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000061290 590__ $$a7.575$$b2016
000061290 591__ $$aPSYCHIATRY$$b6 / 139 = 0.043$$c2016$$dQ1$$eT1
000061290 591__ $$aPSYCHOLOGY, EXPERIMENTAL$$b8 / 142 = 0.056$$c2016$$dQ1$$eT1
000061290 592__ $$a4.121$$b2016
000061290 593__ $$aPsychiatry and Mental Health$$c2016$$dQ1
000061290 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000061290 700__ $$aMacdowell, K.S.
000061290 700__ $$aAlberich, S.
000061290 700__ $$aDiaz, F.J.
000061290 700__ $$aGarcia-Bueno, B.
000061290 700__ $$aRodriguez-Jimenez, R.
000061290 700__ $$aBioque, M.
000061290 700__ $$aBerrocoso, E.
000061290 700__ $$aParellada, M.
000061290 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, A.$$uUniversidad de Zaragoza
000061290 700__ $$aSaiz, P.A.
000061290 700__ $$aMatute, C.
000061290 700__ $$aBernardo, M.
000061290 700__ $$aGonzalez-Pinto, A.
000061290 700__ $$aLeza, J.C.
000061290 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000061290 773__ $$g42, 1 (2016), 142-151$$pSchizophr. bull.$$tSCHIZOPHRENIA BULLETIN$$x0586-7614
000061290 8564_ $$s641028$$uhttps://zaguan.unizar.es/record/61290/files/texto_completo.pdf$$yVersión publicada
000061290 8564_ $$s129374$$uhttps://zaguan.unizar.es/record/61290/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000061290 909CO $$ooai:zaguan.unizar.es:61290$$particulos$$pdriver
000061290 951__ $$a2020-02-21-13:23:47
000061290 980__ $$aARTICLE