000061289 001__ 61289 000061289 005__ 20230421130004.0 000061289 0247_ $$2doi$$a10.1016/j.jagp.2013.02.011 000061289 0248_ $$2sideral$$a90393 000061289 037__ $$aART-2015-90393 000061289 041__ $$aeng 000061289 100__ $$0(orcid)0000-0001-9822-6312$$aGracia-García, P.$$uUniversidad de Zaragoza 000061289 245__ $$aDepression and incident alzheimer disease: The impact of disease severity 000061289 260__ $$c2015 000061289 5060_ $$aAccess copy available to the general public$$fUnrestricted 000061289 5203_ $$aOBJECTIVES: To test the hypothesis that clinically significant depression (particularly severe depression) increases the risk of Alzheimer's disease (AD). METHODS: A longitudinal, three-wave epidemiologic study was implemented in a sample of individuals aged 55 years and older (n = 4,803) followed up at 2.5 years and 4.5 years. This was a population-based cohort drawn from the Zaragoza Dementia and Depression (ZARADEMP) Project, in Zaragoza, Spain. Participants included individuals cognitively intact at baseline (n = 3,864). The main outcome measures were depression as assessed by using the diagnostic interview Geriatric Mental State- Automated Geriatric Examination for Computer Assisted Taxonomy package; and AD diagnosed by a panel of research psychiatrists according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria. The Fine and Gray multivariate regression model was used in the analysis, accounting for mortality. RESULTS: At baseline, clinically significant depression was diagnosed in 452 participants (11.7%); of these, 16.4% had severe depression. Seventy incident cases of AD were found at follow-up. Compared with nondepressed individuals, the incidence rate of AD was significantly higher in the severely depressed subjects (incidence rate ratio: 3.59 [95% confidence interval: 1.30-9.94]). A consistent, significant association was observed between severe depression at baseline and incident AD in the multivariate model (hazard ratio: 4.30 [95% CI: 1.39-13.33]). Untreated depression was associated with incident AD in the unadjusted model; however, in the final model, this association was attenuated and nonsignificant. CONCLUSIONS: Severe depression increases the risk of AD, even after controlling for the competing risk of death. 000061289 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/98-0103$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/G03-128 000061289 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000061289 590__ $$a3.13$$b2015 000061289 591__ $$aPSYCHIATRY$$b30 / 139 = 0.216$$c2015$$dQ1$$eT1 000061289 591__ $$aGERONTOLOGY$$b4 / 32 = 0.125$$c2015$$dQ1$$eT1 000061289 591__ $$aGERIATRICS & GERONTOLOGY$$b15 / 49 = 0.306$$c2015$$dQ2$$eT1 000061289 591__ $$aPSYCHIATRY$$b46 / 142 = 0.324$$c2015$$dQ2$$eT1 000061289 592__ $$a1.757$$b2015 000061289 593__ $$aPsychiatry and Mental Health$$c2015$$dQ1 000061289 593__ $$aGeriatrics and Gerontology$$c2015$$dQ1 000061289 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000061289 700__ $$0(orcid)0000-0003-2284-7862$$aDe-La-Cámara, C.$$uUniversidad de Zaragoza 000061289 700__ $$0(orcid)0000-0002-7297-6104$$aSantabárbara, J.$$uUniversidad de Zaragoza 000061289 700__ $$0(orcid)0000-0002-3360-7015$$aLopez-Anton, R.$$uUniversidad de Zaragoza 000061289 700__ $$0(orcid)0000-0002-4677-8809$$aQuintanilla, M. A.$$uUniversidad de Zaragoza 000061289 700__ $$0(orcid)0000-0002-7470-7207$$aVentura, T.$$uUniversidad de Zaragoza 000061289 700__ $$0(orcid)0000-0001-6836-1222$$aMarcos, G.$$uUniversidad de Zaragoza 000061289 700__ $$0(orcid)0000-0002-5122-7542$$aCampayo, A.$$uUniversidad de Zaragoza 000061289 700__ $$0(orcid)0000-0002-6427-6845$$aSaz, P.$$uUniversidad de Zaragoza 000061289 700__ $$aLyketsos, C. 000061289 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, A.$$uUniversidad de Zaragoza 000061289 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica 000061289 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría 000061289 7102_ $$11008$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Medic.Prevent.Salud Públ. 000061289 773__ $$g23, 2 (2015), 119-129$$pAm. j. geriatr. psychiatry$$tAMERICAN JOURNAL OF GERIATRIC PSYCHIATRY$$x1064-7481 000061289 8564_ $$s435067$$uhttps://zaguan.unizar.es/record/61289/files/texto_completo.pdf$$yPostprint 000061289 8564_ $$s98147$$uhttps://zaguan.unizar.es/record/61289/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000061289 909CO $$ooai:zaguan.unizar.es:61289$$particulos$$pdriver 000061289 951__ $$a2023-04-21-12:38:46 000061289 980__ $$aARTICLE