000060983 001__ 60983
000060983 005__ 20190709135501.0
000060983 0247_ $$2doi$$a10.1038/srep44821
000060983 0248_ $$2sideral$$a98599
000060983 037__ $$aART-2017-98599
000060983 041__ $$aeng
000060983 100__ $$aSánchez-Velázquez, P.
000060983 245__ $$aLong-term effectiveness of irreversible electroporation in a murine model of colorectal liver metastasis
000060983 260__ $$c2017
000060983 5060_ $$aAccess copy available to the general public$$fUnrestricted
000060983 5203_ $$aIrreversible electroporation (IRE) has recently gained in popularity as an ablative technique, however little is known about its oncological long-term outcomes. To determine the long-time survival of animals treated with a high dose of IRE and which histological changes it induces in tumoral tissue, IRE ablation was performed in forty-six athymic-nude mice with KM12C tumors implanted in the liver by applying electric current with different voltages (2000 V/cm, 1000 V/cm). The tumors were allowed to continue to grow until the animals reached the end-point criteria. Histology was harvested and the extent of tumor necrosis was semi-quantitatively assessed. IRE treatment with the 2000 V/cm protocol significantly prolonged median mouse survival from 74.3 ± 6.9 days in the sham group to 112.5 ± 15.2 days in the 2000 V/cm group. No differences were observed between the mean survival of the 1000 V/cm and the sham group (83.2 ± 16.4 days, p = 0.62). Histology revealed 63.05% ± 23.12 of tumor necrosis in animals of the 2000 V/cm group as compared to 17.50% ± 2.50 in the 1000 V/cm group and 25.6% ± 22.1 in the Sham group (p = 0.001). IRE prolonged the survival of animals treated with the highest electric field (2000 V/cm). The animals in this group showed significantly higher rate of tumoral necrosis.
000060983 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/TEC2010-17285$$9info:eu-repo/grantAgreement/ES/MINECO/TEC2011-27133-C02$$9info:eu-repo/grantAgreement/ES/MINECO/TEC2014-52383-C3-2-R$$9info:eu-repo/grantAgreement/ES/MINECO/TEC2014-52383-C3-3-R
000060983 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000060983 590__ $$a4.122$$b2017
000060983 591__ $$aMULTIDISCIPLINARY SCIENCES$$b12 / 64 = 0.188$$c2017$$dQ1$$eT1
000060983 592__ $$a1.533$$b2017
000060983 593__ $$aMultidisciplinary$$c2017$$dQ1
000060983 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000060983 700__ $$aCastellví, Q.
000060983 700__ $$aVillanueva, A.
000060983 700__ $$aIglesias, M.
000060983 700__ $$aQuesada, R.
000060983 700__ $$aPañella, C.
000060983 700__ $$aCáceres, M.
000060983 700__ $$aDorcaratto, D.
000060983 700__ $$aAndaluz, A.
000060983 700__ $$aMoll, X.
000060983 700__ $$0(orcid)0000-0002-9655-5531$$aBurdío, J. M.$$uUniversidad de Zaragoza
000060983 700__ $$aGrande, L.
000060983 700__ $$aIvorra, A.
000060983 700__ $$aBurdío, F.
000060983 7102_ $$15008$$2785$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Tecnología Electrónica
000060983 773__ $$g7 (2017), 44821 [8 pp.]$$pSci. rep.$$tScientific reports$$x2045-2322
000060983 8564_ $$s1575786$$uhttps://zaguan.unizar.es/record/60983/files/texto_completo.pdf$$yVersión publicada
000060983 8564_ $$s107603$$uhttps://zaguan.unizar.es/record/60983/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000060983 909CO $$ooai:zaguan.unizar.es:60983$$particulos$$pdriver
000060983 951__ $$a2019-07-09-11:46:44
000060983 980__ $$aARTICLE