000060976 001__ 60976
000060976 005__ 20190709135529.0
000060976 0247_ $$2doi$$a10.18632/oncotarget.15243
000060976 0248_ $$2sideral$$a98546
000060976 037__ $$aART-2017-98546
000060976 041__ $$aeng
000060976 100__ $$aMateos-Hernández, L.
000060976 245__ $$aTick-host conflict: Immunoglobulin E antibodies to tick proteins in patients with anaphylaxis to tick bite
000060976 260__ $$c2017
000060976 5060_ $$aAccess copy available to the general public$$fUnrestricted
000060976 5203_ $$aTick-borne infectious diseases and allergies are a growing problem worldwide. Tick bite allergy has been associated with the direct effect of immunoglobulin E (IgE) response to tick salivary antigens, or secondary to the induction of allergy to red meat consumption through IgE antibodies against the carbohydrate a-Gal (Gal a 1-3Gal ß 1-(3)4GlcNAc-R). However, despite the growing burden of this pathology, the proteins associated with anaphylaxis to tick bite have not been characterized. To address this question, a comparative proteomics approach was used to characterize tick proteins producing an IgE antibody response in a healthy individual with record of tick bites, which had not resulted in any allergic reactions, and two patients with anaphylactic reactions to Rhipicephalus bursa or Hyalomma marginatum tick bites. Both patients and the healthy individual were red meat tolerant. The results supported a patientspecific IgE antibody response to tick species responsible for the anaphylaxis to tick bite. Both patients and the healthy individual serologically recognized tick proteins with and without a-Gal modifications, with proteins differentially recognized by patients but not control sera. These proteins could be used as potential antigens for diagnostics, treatment and prevention of tick bite-induced allergies.
000060976 536__ $$9info:eu-repo/grantAgreement/EC/FP7/278976/EU/ANTIcipating the Global Onset of Novel Epidemics/ANTIGONE
000060976 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000060976 592__ $$a1.942$$b2017
000060976 593__ $$aOncology$$c2017$$dQ1
000060976 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000060976 700__ $$aVillar, M.
000060976 700__ $$aMoral, A.
000060976 700__ $$aRodríguez, C. G.
000060976 700__ $$aArias, T. A.
000060976 700__ $$ade, la Osa
000060976 700__ $$aBrito, F. F.
000060976 700__ $$ade Mera, I. G. F.
000060976 700__ $$aAlberdi, P.
000060976 700__ $$aRuiz-Fons, F.
000060976 700__ $$aCabezas-Cruz, A.
000060976 700__ $$0(orcid)0000-0001-7483-046X$$aEstrada-Peña, A.$$uUniversidad de Zaragoza
000060976 700__ $$ade, la Fuente
000060976 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000060976 773__ $$g8, 13 (2017), 20630-20644$$pONCOTARGET$$tOncotarget$$x1949-2553
000060976 8564_ $$s4789804$$uhttp://zaguan.unizar.es/record/60976/files/texto_completo.pdf$$yVersión publicada
000060976 8564_ $$s120195$$uhttp://zaguan.unizar.es/record/60976/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000060976 909CO $$ooai:zaguan.unizar.es:60976$$particulos$$pdriver
000060976 951__ $$a2019-07-09-12:01:07
000060976 980__ $$aARTICLE