000060849 001__ 60849
000060849 005__ 20200221144320.0
000060849 0247_ $$2doi$$a10.1016/j.jbiomech.2016.01.043
000060849 0248_ $$2sideral$$a98262
000060849 037__ $$aART-2016-98262
000060849 041__ $$aeng
000060849 100__ $$aWaffenschmidt, T.
000060849 245__ $$aTowards the modelling of ageing and atherosclerosis effects in ApoE-/- mice aortic tissue
000060849 260__ $$c2016
000060849 5060_ $$aAccess copy available to the general public$$fUnrestricted
000060849 5203_ $$aThe goal of this work consists in a quantitative analysis and constitutive modelling of ageing processes associated to plaque formation in mice arteries. Reliable information on the characteristic evolution of pressure–stretch curves due to the ageing effects is extracted from previous inflation test experiments. Furthermore, characteristic age-dependent material parameters are identified on the basis of a continuum-mechanics-based parameter optimisation technique. The results indicate that the aorta-stiffness of the healthy control mice remains basically constant irrespective of the diet-time and age. In contrast, significant differences exist within the material response and in consequence within the material parameters between the ApoE-/- and the control mice as well as for the different locations over the aorta which is underlined by our experimental observations. With regard to the temporal evolution of the material parameters, we observe that the material parameters for the ApoE-/- mice aortas exhibit a saturation-type increase with respect to age.
000060849 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T88$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2013-44391$$9info:eu-repo/grantAgreement/ES/MINECO/PRI-AIBDE-2011-1216
000060849 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000060849 590__ $$a2.664$$b2016
000060849 591__ $$aENGINEERING, BIOMEDICAL$$b25 / 77 = 0.325$$c2016$$dQ2$$eT1
000060849 591__ $$aBIOPHYSICS$$b32 / 73 = 0.438$$c2016$$dQ2$$eT2
000060849 592__ $$a1.242$$b2016
000060849 593__ $$aBiomedical Engineering$$c2016$$dQ1
000060849 593__ $$aBiophysics$$c2016$$dQ1
000060849 593__ $$aSports Science$$c2016$$dQ1
000060849 593__ $$aRehabilitation$$c2016$$dQ1
000060849 593__ $$aOrthopedics and Sports Medicine$$c2016$$dQ1
000060849 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000060849 700__ $$0(orcid)0000-0002-8503-9291$$aCilla, M.
000060849 700__ $$aSáez, P.
000060849 700__ $$aPérez, M.M.
000060849 700__ $$0(orcid)0000-0002-8375-0354$$aMartínez, M.A.$$uUniversidad de Zaragoza
000060849 700__ $$aMenzel, A.
000060849 700__ $$0(orcid)0000-0002-0664-5024$$aPeña, E.$$uUniversidad de Zaragoza
000060849 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000060849 773__ $$g49, 12 (2016), 2390-2397$$pJ. biomech.$$tJournal of Biomechanics$$x0021-9290
000060849 8564_ $$s454894$$uhttps://zaguan.unizar.es/record/60849/files/texto_completo.pdf$$yPostprint
000060849 8564_ $$s77021$$uhttps://zaguan.unizar.es/record/60849/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000060849 909CO $$ooai:zaguan.unizar.es:60849$$particulos$$pdriver
000060849 951__ $$a2020-02-21-13:41:21
000060849 980__ $$aARTICLE