000060693 001__ 60693
000060693 005__ 20190709135443.0
000060693 0247_ $$2doi$$a10.1371/journal.pone.0172698
000060693 0248_ $$2sideral$$a98139
000060693 037__ $$aART-2017-98139
000060693 041__ $$aeng
000060693 100__ $$aGianfagna, F.
000060693 245__ $$aThe role of neuromedin U in adiposity regulation. Haplotype analysis in European children from the IDEFICS Cohort
000060693 260__ $$c2017
000060693 5060_ $$aAccess copy available to the general public$$fUnrestricted
000060693 5203_ $$aBackground and aims Neuromedin U (NMU) is a hypothalamic neuropeptide with important roles in several metabolic processes, recently suggested as potential therapeutic target for obesity. We analysed the associations between NMU gene variants and haplotypes and body mass index (BMI) in a large sample of European children. Methods and results From a large European multi-center study on childhood obesity, 4, 528 children (2.0-9.9 years, mean age 6.0±1.8 SD; boys 52.2%) were randomly selected, stratifying by age, sex and country, and genotyped for tag single nucleotide polymorphisms (SNPs; rs6827359, T:C; rs12500837, T:C; rs9999653, C:T) of NMU gene, then haplotypes were inferred. Regression models were applied to estimate the associations between SNPs or haplotypes and BMI as well as other anthropometric measures. BMI was associated with all NMU SNPs (p<0.05). Among five haplotypes inferred, the haplotype carrying the minor alleles (CCT, frequency = 22.3%) was the only associated with lower BMI values (beta = -0.16, 95%CI:- 0.28, -0.04, p = 0.006; z-score, beta = -0.08, 95%CI:-0.14, -0.01, p = 0.019) and decreased risk of overweight/obesity (OR = 0.81, 95%CI:0.68, 0.97, p = 0.020) when compared to the most prevalent haplotype (codominant model). Similar significant associations were also observed using the same variables collected after two years'' time (BMI, beta = -0.25, 95% CI:-0.41, -0.08, p = 0.004; z-score, beta = -0.10, 95%CI:-0.18, -0.03, p = 0.009; overweight/ obesity OR = 0.81, 95%CI:0.66, 0.99, p = 0.036). The association was age-dependent in girls (interaction between CCT haplotypes and age, p = 0.008), more evident between 7 and 9 years of age. The CCT haplotype was consistently associated with lower levels of fat mass, skinfold thickness, hip and arm circumferences both at T0 and at T1, after adjustment for multiple testing (FDR-adjusted p<0.05). Conclusions This study shows an association between a NMU haplotype and anthropometric indices, mainly linked to fat mass, which appears to be age- and sex-specific in children. Genetic variations within or in linkage with this haplotype should be investigated to identify functional variants responsible for the observed phenotypic variation.
000060693 536__ $$9info:eu-repo/grantAgreement/EUR/FP6/FOOD-016181
000060693 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000060693 590__ $$a2.766$$b2017
000060693 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 64 = 0.234$$c2017$$dQ1$$eT1
000060693 592__ $$a1.164$$b2017
000060693 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2017$$dQ1
000060693 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1
000060693 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2017$$dQ1
000060693 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000060693 700__ $$aGrippi, C.
000060693 700__ $$aAhrens, W.
000060693 700__ $$aBailey, M.E.S.
000060693 700__ $$aBörnhorst, C.
000060693 700__ $$aDe Henauw, S.
000060693 700__ $$aForaita, R.
000060693 700__ $$aKoni, A.C.
000060693 700__ $$aKrogh, V.
000060693 700__ $$aMårild, S.
000060693 700__ $$aMolnár, D.
000060693 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.$$uUniversidad de Zaragoza
000060693 700__ $$aPitsiladis, Y.
000060693 700__ $$aRusso, P.
000060693 700__ $$aSiani, A.
000060693 700__ $$aTornaritis, M.
000060693 700__ $$aVeidebaum, T.
000060693 700__ $$aIacoviello, L.
000060693 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000060693 773__ $$g12, 2 (2017), 0172698 [13 p ]$$pPLoS One$$tPloS one$$x1932-6203
000060693 8564_ $$s955571$$uhttps://zaguan.unizar.es/record/60693/files/texto_completo.pdf$$yVersión publicada
000060693 8564_ $$s108818$$uhttps://zaguan.unizar.es/record/60693/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000060693 909CO $$ooai:zaguan.unizar.es:60693$$particulos$$pdriver
000060693 951__ $$a2019-07-09-11:37:25
000060693 980__ $$aARTICLE