New Organocatalytic Asymmetric Synthesis of Highly Substituted Chiral 2-Oxospiro-[indole-3,4'- (1',4'-dihydropyridine)] Derivatives
Resumen: Herein, we report our preliminary results concerning the first promising asymmetric synthesis of highly functionalized 2-oxospiro-indole-3, 4'-(1', 4'-dihydropyridine)] via the reaction of an enamine with isatylidene malononitrile derivatives in the presence of a chiral base organocatalyst. The moderate, but promising, enantioselectivity observed (30%–58% ee (enantiomeric excess)) opens the door to a new area of research for the asymmetric construction of these appealing spirooxindole skeletons, whose enantioselective syntheses are still very limited.
Idioma: Inglés
DOI: 10.3390/molecules200915807
Año: 2015
Publicado en: MOLECULES 20, 9 (2015), 15807-15826
ISSN: 1420-3049

Factor impacto JCR: 2.465 (2015)
Categ. JCR: CHEMISTRY, ORGANIC rank: 24 / 59 = 0.407 (2015) - Q2 - T2
Factor impacto SCIMAGO:

Financiación: info:eu-repo/grantAgreement/ES/DGA/E104
Financiación: info:eu-repo/grantAgreement/ES/MICINN/CTQ2013-44367-C2-1-P
Financiación: info:eu-repo/grantAgreement/ES/UZ/JIUZ-2014-CIE-07
Tipo y forma: Article (Published version)
Área (Departamento): Química Orgánica (Departamento de Química Orgánica)

Creative Commons You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.


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