000060439 001__ 60439
000060439 005__ 20170504092419.0
000060439 0247_ $$2doi$$a10.1371/journal.pone.0046179
000060439 0248_ $$2sideral$$a78975
000060439 037__ $$aART-2012-78975
000060439 041__ $$aeng
000060439 100__ $$aGarcía-González, M.A.
000060439 245__ $$aPrognostic role of host cyclooxygenase and cytokine genotypes in a caucasian cohort of patients with gastric adenocarcinoma
000060439 260__ $$c2012
000060439 5060_ $$aAccess copy available to the general public$$fUnrestricted
000060439 5203_ $$aBackground: Genetic factors influencing the prognosis of gastric adenocarcinoma (GAC) are not well known. Given the relevance of cytokines and other pro-inflammatory mediators in cancer progression and invasiveness, we aimed to assess the prognostic role of several functional cytokine and cyclooxygenase gene polymorphisms in patients with GAC.
Methodology: Genomic DNA from 380 Spanish Caucasian patients with primary GAC was genotyped for 23 polymorphisms in pro-inflammatory (IL1B, TNFA, LTA, IL6, IL12p40), anti-inflammatory (IL4, IL1RN, IL10, TGFB1) cytokine, and cyclooxygenase (PTGS1 and PTGS2) genes by PCR, RFLP and TaqMan assays. Clinical and histological information was collected prospectively. Survival curves were estimated by the Kaplan-Meier method and compared using the log rank test. Outcome was determined by analysis of Cox proportional hazards, adjusting for confounding factors.
Results: The median follow-up period and median overall survival (OS) time were 9.9 months (range 0.4–120.3) and 10.9 months (95% CI: 8.9–14.1), respectively. Multivariate analysis identified tumor stages III (HR, 3.23; 95% CI:2–5.22) and IV (HR, 5.5; 95% CI: 3.51–8.63) as independent factors associated with a significantly reduced OS, whereas surgical treatment (HR: 0.44; 95%CI: 0.3–0.6) was related to a better prognosis of the disease. Concerning genetic factors, none of the 23 polymor phisms evaluated in the current study did influence survival. Moreover, no gene-environment interactions on GAC prognosis were observed.
Conclusions: Our results show that, in our population, the panel of selected pro- and anti-inflammatory cytokine, and cyclooxygenase gene polymorphisms are not relevant in determining the prognosis of gastric adenocarcinoma.
000060439 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000060439 590__ $$a3.73$$b2012
000060439 591__ $$aMULTIDISCIPLINARY SCIENCES$$b7 / 56 = 0.125$$c2012$$dQ1$$eT1
000060439 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000060439 700__ $$aNicolás-Pérez, D.
000060439 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, A.$$uUniversidad de Zaragoza
000060439 700__ $$aBujanda, L.
000060439 700__ $$aCarrera, P.
000060439 700__ $$0(orcid)0000-0001-5134-1006$$aBenito, R.$$uUniversidad de Zaragoza
000060439 700__ $$aStrunk, M.
000060439 700__ $$0(orcid)0000-0002-8678-4680$$aSopeña, F.$$uUniversidad de Zaragoza
000060439 700__ $$aSantolaria, S.
000060439 700__ $$0(orcid)0000-0001-5813-3445$$aPiazuelo, E.$$uUniversidad de Zaragoza
000060439 700__ $$aJiménez, P.
000060439 700__ $$aCampo, R.
000060439 700__ $$aEspinel, J.
000060439 700__ $$aManzano, M.
000060439 700__ $$aGeijo, F.
000060439 700__ $$aPellisé, M.
000060439 700__ $$aGonzález-Huix, F.
000060439 700__ $$aEspinós, J.
000060439 700__ $$aZaballa, M.
000060439 700__ $$aTitó, L.
000060439 700__ $$aBarranco, L.
000060439 700__ $$aPazo, R.
000060439 700__ $$aQuintero, E.
000060439 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDepartamento de Medicina, Psiquiatría y Dermatología$$cMedicina
000060439 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDepartamento de Farmacología y Fisiología$$cFisiología
000060439 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDepartamento de Microbiología, Medicina Preventiva y Salud Pública$$cMicrobiología
000060439 773__ $$g7, 9 (2012), e46179 [11 pp.]$$pPLoS One$$tPLoS One$$x1932-6203
000060439 8564_ $$s759043$$uhttp://zaguan.unizar.es/record/60439/files/texto_completo.pdf$$yVersión publicada
000060439 8564_ $$s121960$$uhttp://zaguan.unizar.es/record/60439/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000060439 909CO $$ooai:zaguan.unizar.es:60439$$particulos$$pdriver
000060439 951__ $$a2017-05-04-09:18:54
000060439 980__ $$aARTICLE