000058487 001__ 58487
000058487 005__ 20200221144347.0
000058487 0247_ $$2doi$$a10.1007/s10439-015-1486-1
000058487 0248_ $$2sideral$$a92737
000058487 037__ $$aART-2016-92737
000058487 041__ $$aeng
000058487 100__ $$0(orcid)0000-0002-8503-9291$$aCilla, M.
000058487 245__ $$aEffect of diet and age on arterial stiffening due to atherosclerosis in ApoE-/- mice
000058487 260__ $$c2016
000058487 5060_ $$aAccess copy available to the general public$$fUnrestricted
000058487 5203_ $$aThis work analyzes the progressive stiffening of the aorta due to atherosclerosis development of both ApoE-/- and C57BL/6J mice fed on a Western (n = 5) and a normal (n = 5) chow diet for the ApoE-/- group and on a normal chow diet (n = 5) for the C57BL/6J group. Sets of 5 animals from the three groups were killed after 10, 20, 30 and 40 weeks on their respective diets (corresponding to 17, 27, 37 and 47 weeks of age). Mechanical properties (inflation test and axial residual stress measurements) and histological properties were compared for both strains, ApoE-/- on the hyper-lipidic diet and both ApoE-/- and C57BL/6J on the normal diet, after the same period and after different periods of diet. The results indicated that the aorta stiffness in the ApoE-/- and C57BL/6J mice under normal diet remained approximately constant irrespective of their age. However, the arterial stiffness in the ApoE-/- on the hyper-lipidic diet increased over time. Statistical differences were found between the group after 10 weeks and the groups after 30 and 40 weeks of a hyper-lipidic diet. Comparing the hyper-lipidic and normal diet mice, statistical differences were also found between both diets in all cases after 40 weeks of diet, frequently after 30 weeks, and in some cases after 20 weeks. The early stages of lesion corresponded to the first 2 weeks of diet. Advanced lesions were found at 30 weeks and, finally, the aorta was completely damaged after 40 weeks of diet. In conclusion, we found substantial changes in the mechanical properties of the aorta walls of the ApoE-/- mice fed with the hyper-lipidic diet compared to the normal chow diet groups for both the ApoE-/- and C57BL/6J groups. These findings could serve as a reference for the study of changes in the arterial wall properties in cases of atherosclerosis.
000058487 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T88$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2013-44391-P$$9info:eu-repo/grantAgreement/ES/MINECO/PRI-AIBDE-2011-1216$$9info:eu-repo/grantAgreement/ES/UZ/2008-BIO-21
000058487 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000058487 590__ $$a3.221$$b2016
000058487 591__ $$aENGINEERING, BIOMEDICAL$$b18 / 77 = 0.234$$c2016$$dQ1$$eT1
000058487 592__ $$a1.096$$b2016
000058487 593__ $$aBiomedical Engineering$$c2016$$dQ1
000058487 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000058487 700__ $$0(orcid)0000-0002-8133-2124$$aPérez, M.M.$$uUniversidad de Zaragoza
000058487 700__ $$0(orcid)0000-0002-0664-5024$$aPeña, E.$$uUniversidad de Zaragoza
000058487 700__ $$0(orcid)0000-0002-8375-0354$$aMartínez, M.A.$$uUniversidad de Zaragoza
000058487 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com
000058487 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000058487 773__ $$g44, 7 (2016), 2202–2217$$pAnn. biomed. eng.$$tANNALS OF BIOMEDICAL ENGINEERING$$x0090-6964
000058487 8564_ $$s4310825$$uhttps://zaguan.unizar.es/record/58487/files/texto_completo.pdf$$yPostprint
000058487 8564_ $$s66117$$uhttps://zaguan.unizar.es/record/58487/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000058487 909CO $$ooai:zaguan.unizar.es:58487$$particulos$$pdriver
000058487 951__ $$a2020-02-21-13:53:08
000058487 980__ $$aARTICLE