000057927 001__ 57927
000057927 005__ 20170601140244.0
000057927 0247_ $$2doi$$a10.1186/1471-244X-14-84
000057927 0248_ $$2sideral$$a86924
000057927 037__ $$aART-2014-86924
000057927 041__ $$aeng
000057927 100__ $$aPoblador-Plou, B.
000057927 245__ $$aComorbidity of dementia: A cross-sectional study of primary care older patients
000057927 260__ $$c2014
000057927 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057927 5203_ $$aBackground: The epidemiologic study of comorbidities of an index health problem represents a methodological challenge. This study cross-sectionally describes and analyzes the comorbidities associated with dementia in older patients and reviews the existing similarities and differences between identified comorbid diseases using the statistical methods most frequently applied in current research.
Methods: Cross-sectional study of 72,815 patients over 64 seen in 19 Spanish primary care centers during 2008. Chronic diseases were extracted from electronic health records and grouped into Expanded Diagnostic Clusters®. Three different statistical methods were applied (i.e., analysis of prevalence data, multiple regression and factor analysis), stratifying by sex.
Results: The two most frequent comorbidities both for men and women with dementia were hypertension and diabetes. Yet, logistic regression and factor analysis demonstrated that the comorbidities significantly associated with dementia were Parkinson’s disease, congestive heart failure, cerebrovascular disease, anemia, cardiac arrhythmia, chronic skin ulcers, osteoporosis, thyroid disease, retinal disorders, prostatic hypertrophy, insomnia and anxiety and neurosis.
Conclusions: The analysis of the comorbidities associated with an index disease (e.g., dementia) must not be exclusively based on prevalence rates, but rather on methodologies that allow the discovery of non-random associations between diseases. A deep and reliable knowledge about how different diseases are grouped and associated around an index disease such as dementia may orient future longitudinal studies aimed at unraveling causal associations.
000057927 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI11-01126
000057927 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057927 590__ $$a2.21$$b2014
000057927 591__ $$aPSYCHIATRY$$b71 / 139 = 0.511$$c2014$$dQ3$$eT2
000057927 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057927 700__ $$0(orcid)0000-0001-9064-9222$$aCalderón-Larrañaga, A.
000057927 700__ $$0(orcid)0000-0002-5457-9973$$aMarta-Moreno, J.$$uUniversidad de Zaragoza
000057927 700__ $$aHancco-Saavedra, J.
000057927 700__ $$aSicras-Mainar, A.
000057927 700__ $$aSoljak, M.
000057927 700__ $$0(orcid)0000-0002-5704-6056$$aPrados-Torres, A.$$uUniversidad de Zaragoza
000057927 7102_ $$11008$$2615$$aUniversidad de Zaragoza$$bDepartamento de Microbiología, Medicina Preventiva y Salud Pública$$cMedicina Preventiva y Salud Pública
000057927 7102_ $$11006$$2413$$aUniversidad de Zaragoza$$bDepartamento de Fisiatría y Enfermería$$cFisioterapia
000057927 773__ $$g14, 1 (2014), 84 [8 pp]$$pBMC Psychiatry$$tBMC Psychiatry$$x1471-244X
000057927 8564_ $$s593102$$uhttp://zaguan.unizar.es/record/57927/files/texto_completo.pdf$$yVersión publicada
000057927 8564_ $$s102358$$uhttp://zaguan.unizar.es/record/57927/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057927 909CO $$ooai:zaguan.unizar.es:57927$$particulos$$pdriver
000057927 951__ $$a2017-06-01-13:58:25
000057927 980__ $$aARTICLE